Yang Li
Anhui Medical University
14 Papers
7 Citations
Yang Li is an academic researcher from Anhui Medical University. The author has contributed to research in topics: Cancer stem cell & Cancer. The author has an hindex of 7, co-authored 10 publications. Previous affiliations of Yang Li include University of California, Los Angeles.
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Papers
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
Maosheng Cheng,Lu Sheng,Qian Gao,Qiuchan Xiong,Haojie Zhang,Mingqing Wu,Yu Liang,Fengyu Zhu,Yingyin Zhang,Xiuhong Zhang,Quan Yuan,Yang Li +11 more
TL;DR: An AFF4/NF-κB/MYC signaling network operated by METTL3-mediated m6A modification is uncovered and insight into the mechanisms of BCa progression is provided.
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CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance.
Cheng Wang,Yang Li,Lingfei Jia,Jin Koo Kim,Jiong Li,Peng Deng,Wuchang Zhang,Paul H. Krebsbach,Cun-Yu Wang +8 more
TL;DR: This article showed that CSCs upregulate the immune checkpoint molecule CD276 (B7-H3) to evade host immune responses and showed that anti-CD276 antibodies eliminate CSC in a CD8+ T-cell-dependent manner, inhibiting tumor growth and lymph node metastases in a mouse HNSCC model.
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Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma.
TL;DR: In this article, super-enhancers play a critical role in the transcription of cancer stemness genes as well as pro-metastatic genes, thereby controlling their tumorigenic potential and metastasis.
SOX2 Is a Marker for Stem-like Tumor Cells in Bladder Cancer
Fengyu Zhu,Qian Weiqing,Haojie Zhang,Yu Liang,Mingqing Wu,Yingyin Zhang,Xiuhong Zhang,Qian Gao,Yang Li +8 more
TL;DR: The data show that Sox2 is a marker of bladder CSCs and indicate it as a potential clinical target for BCa therapy, and shows the essential role of SOX2-positive cells in regulating BCa maintenance and progression.
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JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA.
Zegui Ni,Pengli Sun,Mingqing Wu,Congcong Yang,Maosheng Cheng,Mingwei Yin,Chengying Cui,Guangxian Wang,Lin Yuan,Qian Gao,Yang Li +10 more
TL;DR: It is found that activated JNK signaling is associated with increased METTL3 expression in bladder cancer and the identification of a novel m6A-dependent mechanism underlying immune system evasion by bladder cancer cells reveals J NK signaling as a potential target for bladder cancer immunotherapy.
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