The methodological advancements in surface-enhanced Raman scattering (SERS) technique with nanoscale materials based on noble metals, Au, Ag, and their bimetallic alloy Au-Ag, has enabled the highly efficient sensing of chemical and biological molecules at very low concentration values. By employing the innovative various type of Au, Ag nanoparticles and especially, high efficiency Au@Ag alloy nanomaterials as substrate in SERS based biosensors have revolutionized the detection of biological components including; proteins, antigens antibodies complex, circulating tumor cells, DNA, and RNA (miRNA), etc. This review is about SERS-based Au/Ag bimetallic biosensors and their Raman enhanced activity by focusing on different factors related to them. The emphasis of this research is to describe the recent developments in this field and conceptual advancements behind them. Furthermore, in this article we apex the understanding of impact by variation in basic features like effects of size, shape varying lengths, thickness of core-shell and their influence of large-scale magnitude and morphology. Moreover, the detailed information about recent biological applications based on these core-shell noble metals, importantly detection of receptor binding domain (RBD) protein of COVID-19 is provided. 

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/EXP.20220072

Recent advances of Au@Ag core–shell SERS‐based biosensors

The reality that the coronavirus disease 2019 (COVID-19) is still raging around the world and making a comeback with a strong presence has highlighted the need for rapid and sensitive quantitative detection methods of viral RNA, antibody and antigen for widespread tracking and screening applications. Surface plasmon resonance (SPR) detection technology has achieved rapid development and become a standard measurement method in the fields of biosensing, biomedicine, biochemistry and biopharmaceuticals due to its advantages of high sensitivity, fast response and no need for labelling. Here, we report a sandwiched structure-based SPR biosensor for detecting a specific viral antigen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike S1 protein. The sensor combines a Ti3C2-MXene nanosheet modified sensing platform and polydopamine (PDA)-Ag nanoparticle (AgNP)/anti-SARS-CoV-2 spike S1 protein nanoconjugate signal enhancers, exhibiting a wide linear range of 0.0001 to 1000 ng mL-1 with a low detection limit of 12 fg mL-1 (S/N = 3). In the analysis of artificial saliva and human serum samples, the proposed SPR biosensor exhibits good reproducibility and high specificity, which indicates its potential for application in complex bodily fluids. The exploitation of the MXene-based SPR biochip for recognizing the SARS-CoV-2 antigen provides an accessible and rapid way for COVID-19 diagnosis, and promotes the application of 2D nanomaterial-based sensing chips in clinical diagnosis and disease screening. Significantly, the proposed method possesses general applicability that can be reprogrammed to detect any protein antigen if a corresponding specific nanobody is available.

Highly sensitive and selective surface plasmon resonance biosensor for the detection of SARS-CoV-2 spike S1 protein.

Industrial wastewater containing large amounts of organic pollutants is a severe threat to the environment and human health. Thus, the rapid detection and removal of these pollutants from wastewater are essential to protect public health and the ecological environment. In this study, a multifunctional and reusable surface-enhanced Raman scattering (SERS) substrate by growing Ag nanoparticles (NPs) on ZnO nanorods (NRs) was produced for detecting and degrading Rhodamine B (RhB) dye. The ZnO/Ag substrate exhibited excellent sensitivity, and the limit of detection (LOD) for RhB was as low as 10−11 M. Furthermore, the SERS substrate could efficiently degrade RhB, with a degradation efficiency of nearly 100% within 150 min. Moreover, it retained good SERS activity after multiple repeated uses. The interaction between Ag NPs, ZnO, and RhB was further investigated, and the mechanism of SERS and photocatalysis was proposed. The as-prepared ZnO/Ag composite structure could be highly applicable as a multifunctional SERS substrate for the rapid detection and photocatalytic degradation of trace amounts of organic pollutants in water.

/pdf/ag-nanoparticles-decorated-zno-nanorods-as-multifunctional-vq3xjslb.pdf

Ag Nanoparticles Decorated ZnO Nanorods as Multifunctional SERS Substrates for Ultrasensitive Detection and Catalytic Degradation of Rhodamine B

Continuing progress in the field of two-dimensional correlation spectroscopy (2D-COS): Part III. Versatile applications.

Abstract As detection of cancer and diabetes diseases has captured a great attention in the field of biosensing, many ways were introduced to detect these diseases with high accuracy. This paper presents a novel use of zinc selenide (ZnSe) semiconductor material to enhance the sensitivity of a conventional Ag-based surface plasmon resonance biosensor. The proposed sensor structure is simple (BK7 prism/Ag/ZnSe), cost-effective, and easy to design and fabricate. The sensor is tested in the detection of different cancerous cells in human blood, showing an excellent sensitivity of 359 $$^\circ$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow /> <mml:mo>∘</mml:mo> </mml:msup> </mml:math> /RIU. In addiion, it is tested to detect various glucose levels in human urine, and it provides a very high performance with a sensitivity of 366.6 $$^\circ$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow /> <mml:mo>∘</mml:mo> </mml:msup> </mml:math> /RIU, which is 70% better than that of a similar reported work. Thus, the proposed biosensor is capable efficiently to detect various kinds of cancer cells and different glucose concentrations in urine. 

https://link.springer.com/content/pdf/10.1007/s11082-022-04326-y.pdf

ZnSe-based highly-sensitive SPR biosensor for detection of different cancer cells and urine glucose levels

Surface plasmon resonance induced charge transfer effect on the Ag-ZnSe-PATP system.

Na2Ti3O7 (NTO) is recognized as an authenticated promising photocatalyst and surface-enhanced Raman scattering (SERS) active material, although its performance is limited by its high carrier recombination rate, wide band gap...

Ag Decoration on Na2Ti3O7 Nanowires for Improved SERS and PHE Performance

Novel insight into charge transfer regulation based on carrier density-dependent Ag/ITO composite films.

The localized surface plasmon resonance (LSPR) of Ag/indium tin oxide (ITO)@polystyrene (PS) in the visible-NIR region was dependent on the tuning of the carrier density caused by adjusting the thickness of the ITO layer. The two-dimensional correlation spectroscopy (2D-COS) results of the dependence of each component in the UV-vis-NIR spectrum on the carrier density response enabled the successful exploration of the carrier transport process.

New insight into SPR modulating by two-dimensional correlation spectroscopy: the case for an Ag/ITO system

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Surface plasmon resonance induced charge transfer effect on the Ag-ZnSe-PATP system.

Ag Decoration on Na2Ti3O7 Nanowires for Improved SERS and PHE Performance

Novel insight into charge transfer regulation based on carrier density-dependent Ag/ITO composite films.

New insight into SPR modulating by two-dimensional correlation spectroscopy: the case for an Ag/ITO system