Yang He
Chinese Academy of Sciences
28 Papers
98 Citations
Yang He is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Chemistry & hERG. The author has an hindex of 9, co-authored 26 publications.
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Papers
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target.
Bingqing Xia,Xurui Shen,Yang He,Xiaoyan Pan,Feng-Liang Liu,Yi Wang,Feipu Yang,Sui Fang,Yan Wu,Zilei Duan,Xiaoli Zuo,Zhuqing Xie,Zhuqing Xie,Xiangrui Jiang,Ling Xu,Hao Chi,Shuang-Qu Li,Qian Meng,Hu Zhou,Yubo Zhou,Xi Cheng,Xiaoming Xin,Lin Jin,Hai-Lin Zhang,Dan dan Yu,Ming-Hua Li,Xiao Li Feng,Jiekai Chen,Hualiang Jiang,Gengfu Xiao,Yong-Tang Zheng,Lei Ke Zhang,Jingshan Shen,Jia Li,Zhaobing Gao +34 more
TL;DR: In this article, the authors showed that the SARS-CoV-2 envelope (2-E) protein alone is able to cause acute respiratory distress syndrome (ARDS)-like damages in vitro and in vivo.
Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors.
Jing Ren,Yang He,Wuyan Chen,Tiantian Chen,Guan Wang,Zhen Wang,Zhijian Xu,Xiaomin Luo,Weiliang Zhu,Hualiang Jiang,Jingshan Shen,Yechun Xu +11 more
TL;DR: The first comprehensive thermodynamic and structural characterization of halogen bonding in PDE5-inhibitor interactions is presented, revealing that binding strength of the halogen bonded between chlorine, bromine, and iodine of inhibitor and the protein is -1.57 kJ/mol.
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Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
Zhen Wang,Xiangrui Jiang,Xianglei Zhang,Guanghui Tian,Rulei Yang,Jianzhong Wu,Xiaoli Zou,Zheng Liu,Xiaojun Yang,Chunhui Wu,Jing Shi,Jianfeng Li,Jin Suo,Yu Wang,Rongxia Zhang,Zhijian Xu,Xudong Gong,Yang He,Weiliang Zhu,Haji Akber Aisa,Hualiang Jiang,Yechun Xu,Jingshan Shen +22 more
TL;DR: A pharmacokinetics-driven optimization focusing on the terminal substituent of compound 15 (TPN171) with subnanomolar potency for PDE5 and good selectivity over PDE6 was finally recognized as a potential drug candidate, and its pharmacokinetic profiles in rats and dogs are significantly improved compared to the starting compound.
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Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus.
Melkamu Alemu Abame,Yang He,Song Wu,Zhifei Xie,Jian Zhang,Xudong Gong,Chunhui Wu,Jingshan Shen +7 more
TL;DR: In this paper, the authors investigated the effect of CBD after chronic administration (7 days) and concluded that chronic CBD (100 mg/kg) induced antidepressant-like effects by increasing 5-HT and noradrenaline levels in the hippocampus.
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Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect.
Mingshuo Xu,Yu Wang,Feipu Yang,Chunhui Wu,Zhen Wang,Bin Ye,Xiangrui Jiang,Qingjie Zhao,Jianfeng Li,Yongjian Liu,Junchi Zhang,Guanghui Tian,Yang He,Jingshan Shen,Hualiang Jiang +14 more
TL;DR: In animal behavioral studies, compound 3d reduced phencyclidine-induced hyperlocomotion with a high threshold for catalepsy induction, suggesting a low liability to induce side effects such as weight gain, orthostatic hypotension and QT prolongation.
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