Yang Gao
Wuhan University
23 Papers
37 Citations
Yang Gao is an academic researcher from Wuhan University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 10, co-authored 18 publications.
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Papers
CSCD: a database for cancer-specific circular RNAs
Siyu Xia,Jing Feng,Ke Chen,Yanbing Ma,Jing Gong,Fangfang Cai,Yuxuan Jin,Yang Gao,Linjian Xia,Hong Chang,Lei Wei,Leng Han,Chunjiang He +12 more
TL;DR: A cancer-specific circRNA database is constructed (CSCD) that could significantly contribute to the research for the function and regulation of cancer-associated circRNAs.
CircRNA inhibits DNA damage repair by interacting with host gene
Xiaolong Xu,Jingwei Zhang,Yihao Tian,Yang Gao,Xin Dong,Wenbo Chen,Xiaoning Yuan,Weinan Yin,Jinjing Xu,Ke Chen,Chunjiang He,Chunjiang He,Lei Wei +12 more
TL;DR: It is demonstrated that circSMARCA5 can bind to its parent gene locus, forming an R-loop, which results in transcriptional pausing at exon 15 of SMarCA5, which revealed a new regulatory mechanism for circRNA on its host gene and provided evidence that circ SMAR CA5 may serve as a therapeutic target for drug-resistant breast cancer patients.
Genome-wide identification of cancer-specific alternative splicing in circRNA.
Jing Feng,Ke Chen,Xin Dong,Xiaolong Xu,Yuxuan Jin,Xinyang Zhang,Wenbo Chen,Yujing Han,Lin Shao,Yang Gao,Chunjiang He +10 more
TL;DR: This study presents the first comprehensive view of cancer-specific circRNA alternative splicing, which could contribute significantly to regulation and functional research of circRNAs in cancers.
MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2
Xiaolong Xu,Xiaoning Yuan,Jiali Ni,Jing Guo,Yang Gao,Weinan Yin,Feng Li,Lei Wei,Jingwei Zhang +8 more
TL;DR: Gene structure and DNA methylation analysis results indicated that MAGI2‐AS3 may act as a cis‐acting regulatory element downregulating theDNA methylation level of the MAGI 2 promoter region, and the DNA demethylase TET1 inhibitor can reverse MAGI1‐ AS3 overexpression caused upregulation of MAGI3 and cellular effects.
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Silencing lncRNA SNHG6 suppresses proliferation and invasion of breast cancer cells through miR-26a/VASP axis.
Kai Li,Yanbin Ma,Yihao Tian,Xiaolong Xu,Yang Gao,Yanqi He,Wenting Pan,Jingwei Zhang,Chunjiang He,Lei Wei +9 more
TL;DR: The important role of the SNHG6/miR-26a/VASP regulatory network in the development of breast cancer is revealed, and a reference for exploring new pathogenesis and biomarkers of Breast cancer is provided.
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