Yang-Chieh Chou
University of Toronto
11 Papers
127 Citations
Yang-Chieh Chou is an academic researcher from University of Toronto. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 10, co-authored 11 publications. Previous affiliations of Yang-Chieh Chou include National Yang-Ming University & National Research Council.
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Papers
An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme
Derek F. Ceccarelli,Xiaojing Tang,Benoit Pelletier,Stephen Orlicky,Weilin Xie,Veronique Plantevin,Dante Neculai,Dante Neculai,Yang-Chieh Chou,Yang-Chieh Chou,Abiodun A. Ogunjimi,Abdallah Al-Hakim,Xaralabos Varelas,Joanna Koszela,Gregory A. Wasney,Masoud Vedadi,Sirano Dhe-Paganon,Sarah Cox,Shuichan Xu,Antonia Lopez-Girona,Frank Mercurio,Jeff Wrana,Daniel Durocher,Sylvain Meloche,David R. Webb,Mike Tyers,Mike Tyers,Mike Tyers,Frank Sicheri,Frank Sicheri +29 more
TL;DR: E2 enzymes are susceptible to noncatalytic site inhibition and may represent a viable class of drug target in the UPS.
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The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
Nathalie Meyer-Schaller,Yang-Chieh Chou,Izabela Sumara,Dale D.O. Martin,Thimo Kurz,Nadja Katheder,Kay Hofmann,Luc G. Berthiaume,Frank Sicheri,Matthias Peter +9 more
TL;DR: It is concluded that DCNL proteins function as nonredundant Cul Nedd8-E3 ligases, and the diversification of the N termini in mammalian Dcn1 homologues may contribute to substrate specificity by regulating their subcellular localization.
92
The Role of Apoptosis Signal-regulating Kinase 1 in Lymphotoxin-β Receptor-mediated Cell Death
Mei Chieh Chen,Ming-Jing Hwang,Yang-Chieh Chou,Wei Hsu Chen,Genhong Cheng,Hiroyasu Nakano,Tien-Yau Luh,Shen Chih Mai,Shie Liang Hsieh,Shie Liang Hsieh +9 more
TL;DR: A LIGHT mutein, LIGHT-R228E, was shown to exhibit similar binding specificity as wild type LIGHT to LTβR, but lose the ability to interact with herpes virus entry mediator, which suggests that ASK1 is one of the factors involved in the caspase-independent pathway of LT βR-induced cell death.
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Conserved structural mechanisms for autoinhibition in IpaH ubiquitin ligases.
TL;DR: It is demonstrated that the leucine-rich repeat (LRR) substrate recognition domains of different IpaH enzymes autoinhibit the enzymatic activity of the adjacent catalytic novel E3 ligase domain by two distinct but conserved structural mechanisms.
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Inhibition of Lymphotoxin-β Receptor–Mediated Cell Death by Survivin-ΔEx3
TL;DR: It is found that both Kaposi's sarcoma-associated herpesvirus K7 (KSHV-K7), a viral inhibitor of apoptosis protein, and the structurally related protein survivin-DeltaEx3 could inhibit LTbetaR-mediated caspase-3 activation, however, only surviv in-Delta ex3 could protect cells from LT betaR- mediated cell death.
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