Yang Chen
China Pharmaceutical University
5 Papers
Yang Chen is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Medicine & Diarrhea. The author has an hindex of 1, co-authored 1 publications.
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Papers
Development of an itraconazole encapsulated polymeric nanoparticle platform for effective antifungal therapy
Xiang Ling,Xiang Ling,Zewei Huang,Jianzhao Wang,Jiarong Xie,Feng Min,Yang Chen,Farhana Abbas,Jiasheng Tu,Jun Wu,Chunmeng Sun +10 more
TL;DR: The developed ITZ-NPs could reduce systemic toxicity, improve antifungal activity and act as a potential intravenous formulation of ITZ, indicating much better biocompatibility than marketed cyclodextrin formulations ofITZ.
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The Multi-Omics Analysis Revealed a Metabolic Regulatory System of Cecum in Rabbit with Diarrhea
TL;DR: The results of correlation analysis showed that Fournierella was positively correlated with myricetin, ursolic acid, and furtherly might cause bile secretion and tryptophan metabolism disorder, aggravate intestinal inflammation, change intestinal permeability, and reduce host immunity, leading to diarrhea in rabbits.
New compound probiotic beverage protects against antibiotic-associated diarrhea in mice by modulating the microbiota.
Yang Chen,S. Lu,Zhiwei Ye,Xin Cai,Shanshan Wu,Pan Li,Bing Du +6 more
TL;DR: The combinations of probiotic beverages effectively caused structural recovery of the gut and fecal microbiota against antibiotic-associated diarrhea, and the S1 formula showed the best efficacy.
3
Probiotic-fermented Qushi decoction alleviates reserpine induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis.
TL;DR: This paper investigated the splenic protection of probiotic fermented Qushi decoction (FQD) in Spleen deficiency syndrome (SDS) rats by modulating gastrointestinal motility hormones and intestinal microbiota and found that FQD increased total polysaccharides, total protein, total flavonoids and the other active ingredients compared to QD, effectively improved splenic inflammation and apoptosis in SDS rats, and modulated gastrointestinal motile hormones to alleviate diarrhoea and other symptoms.
2
The Multi-Omics Analysis Revealed Microbiological Regulation of Rabbit Colon with Diarrhea Fed an Antibiotic-Free Diet
TL;DR: The significantly upregulated differential genes were mainly enriched in the IL-17 signaling pathway and were involved in promoting inflammatory response, and the colonic epithelial cells were damaged, affecting the function of the colon and leading to diarrhea in rabbits.