Yanbin Wu
Peking Union Medical College
9 Papers
15 Citations
Yanbin Wu is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Chemistry & Gram-negative bacteria. The author has an hindex of 7, co-authored 9 publications.
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Papers
Novel carbazole sulfonamide derivatives of antitumor agent: Synthesis, antiproliferative activity and aqueous solubility
TL;DR: Two compounds were more active than 3 and their activity against HepG2 and MCF-7 approached that of the positive controls podophyllotoxin (podo) and CA-4, which warrant further development of new compounds 13f and 13i as potential potent antitumor drug candidates.
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Synthesis and structure-activity relationship of novel bisindole amidines active against MDR Gram-positive and Gram-negative bacteria.
TL;DR: A series of novel diamidines with N-substituents on an amidine N-atom were synthesized and evaluated for their cytotoxicity and in vitro antibacterial activity against a range of Gram-positive and Gram-negative bacterial strains; compounds 5c and 5i were the most powerful candidate compounds.
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Prediction of bioactivity of HIV-1 integrase ST inhibitors by multilinear regression analysis and support vector machine.
TL;DR: In this study, four computational quantitative structure-activity relationship models were built to predict the biological activity of HIV-1 integrase strand transfer (ST) inhibitors.
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Novel carbazole sulfonamide microtubule-destabilizing agents exert potent antitumor activity against esophageal squamous cell carcinoma.
Fangfei Niu,Liu Yonghua,Zongpan Jing,Gaijing Han,Lianqi Sun,Lu Yan,Lanping Zhou,Yanbin Wu,Yang Xu,Laixing Hu,Xiaohang Zhao +10 more
TL;DR: Results indicate that SL-3-19 may be a new therapeutic candidate for ESCC treatment, and novel microtubule-destabilizing agents that have a potential antitumor effect on ESCC both in–vitro and in vivo.
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Synthesis and in vitro activity of dicationic indolyl diphenyl ethers as novel potent antibiotic agents against drug-resistant bacteria.
TL;DR: Interestingly, 7j had greatly improved anti negative bacterial activity, especially for the producing NDM-1 Klebsiella pneumonia strain and less toxic than that of the lead compound 2.
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