Yanai Duran
UCL Institute of Ophthalmology
40 Papers
122 Citations
Yanai Duran is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Retina & Retinal degeneration. The author has an hindex of 25, co-authored 40 publications. Previous affiliations of Yanai Duran include University College London.
Chat about Author
Papers
Effective gene therapy with nonintegrating lentiviral vectors
Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Kamaljit S. Balaggan,A MacNeil,Steven J. Howe,Manfred Schmidt,Manfred Schmidt,Alexander J. Smith,Prateek K. Buch,Robert E MacLaren,Patrick N. Anderson,S. E. Barker,Yanai Duran,CC Bartholomae,CC Bartholomae,Christof von Kalle,John R. Heckenlively,Christine Kinnon,Robin R. Ali,Adrian J. Thrasher +20 more
TL;DR: The high efficiency of gene transfer and expression mediated by lentiviruses can be harnessed in vivo without a requirement for vector integration and substantially reduces the risk of insertional mutagenesis.
512
Restoration of vision after transplantation of photoreceptors
Rachael A. Pearson,Amanda C. Barber,Matteo Rizzi,Claire Hippert,Tian Xue,Emma L. West,Yanai Duran,Alexander J. Smith,Jen-Zen Chuang,Selina A. Azam,Ulrich F O Luhmann,Andrea Benucci,Ching-Hwa Sung,James W B Bainbridge,Matteo Carandini,King Wai Yau,Jane C. Sowden,Robin R. Ali,Robin R. Ali +18 more
TL;DR: Evidence of functional rod-mediated vision after photoreceptor transplantation in adult Gnat1−/− mice is provided and it is demonstrated that visual signals generated by transplanted rods are projected to higher visual areas, including V1.
502
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.
Rachael A. Pearson,Anai Gonzalez-Cordero,Emma L. West,J. R. Ribeiro,Nozie D. Aghaizu,Debbie Goh,Robert D. Sampson,Anastasios Georgiadis,P. V. Waldron,Yanai Duran,Arifa Naeem,Magdalena Kloc,E. Cristante,Kamil Kruczek,Katherine Warre-Cornish,Jane C. Sowden,Andrew Smith,Robin R. Ali,Robin R. Ali +18 more
TL;DR: It is shown that while integration occurs the majority of donor-reporter-labelled cells in the host arises as a result of material transfer between donor and host photoreceptors, raising the possibility of materialtransfer as a strategy for the treatment of retinal disorders.
Repair of the degenerate retina by photoreceptor transplantation
Amanda C. Barber,Claire Hippert,Yanai Duran,Emma L. West,James W B Bainbridge,Katherine Warre-Cornish,Ulrich F O Luhmann,Jorn Lakowski,Jane C. Sowden,Robin R. Ali,Rachael A. Pearson +10 more
TL;DR: It is possible to achieve robust integration across a broad range of inherited retinopathies, even in late-stage disease, and transplantation outcome can be improved by administering appropriate, tailored manipulations of the recipient environment.
288
Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors
Anai Gonzalez-Cordero,Kamil Kruczek,Arifa Naeem,Milan Fernando,Magdalena Kloc,Joana Ribeiro,Debbie Goh,Yanai Duran,Samuel J.I. Blackford,Laura Abelleira-Hervas,Robert D. Sampson,Ian O. Shum,Matthew J. Branch,Peter Gardner,Jane C. Sowden,James W B Bainbridge,Alexander J. Smith,Emma L. West,Rachael A. Pearson,Robin R. Ali,Robin R. Ali +20 more
TL;DR: A modified 2D/3D protocol is reported for generating hPSC-derived neural retinal vesicles with well-formed ONL-like structures containing cones and rods bearing inner segments and connecting cilia, nascent outer segments, and presynaptic structures that recapitulates human photoreceptor development, allowing the isolation and transplantation of a pure population of stage-matched cones.
224