6 Papers
Yana Wang is an academic researcher from East Tennessee State University James H. Quillen College of Medicine. The author has contributed to research in topics: Endothelial stem cell & Sepsis. The author has an hindex of 4, co-authored 6 publications. Previous affiliations of Yana Wang include Nanjing Medical University.
Chat about Author
Papers
Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis.
Kun Yang,Kun Yang,Min Fan,Min Fan,Xiaohui Wang,Xiaohui Wang,Jingjing Xu,Yana Wang,Fei Tu,P. Spencer Gill,Tuanzhu Ha,Tuanzhu Ha,Li Liu,David L. Williams,David L. Williams,Chuanfu Li,Chuanfu Li +16 more
TL;DR: In this paper, the authors demonstrated a role of lactate in HMGB1 lactylation and acetylation in macrophages during polymicrobial sepsis and found that macrophage can uptake extracellular lactate via monocarboxylate transporters (MCTs) to promote HMGB 1 lactylation via a p300/CBP-dependent mechanism.
Cardiomyocyte-specific deficiency of HSPB1 worsens cardiac dysfunction by activating NFκB-mediated leucocyte recruitment after myocardial infarction.
Yana Wang,Jiali Liu,Qiuyue Kong,Hao Cheng,Fei Tu,Peng Yu,Ying Liu,Xiaojin Zhang,Chuanfu Li,Yuehua Li,Xinxu Min,Shuya Du,Zhengnian Ding,Li Liu +13 more
TL;DR: Data suggest that HSPB1 acts as a negative regulator of NFκB-mediated leucocyte recruitment and the subsequent inflammation in cardiomyocytes, which is required for wound healing after MI and could be a target for myocardial repair in MI patients.
49
Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis.
Fei Tu,Xiaohui Wang,Xia Zhang,Tuanzhu Ha,Yana Wang,Min Fan,Kun Yang,P. Spencer Gill,Tammy R. Ozment,Yuan Dai,Li Liu,David L. Williams,Chuanfu Li +12 more
TL;DR: The data suggest that endothelial HSPA12B plays a novel role in the regulation of macrophage pro-inflammatory response via exosomes during sepsis and that sepsi induced cardiomyopathy and mortality are associated with endothelial cell deficiency of HSPA 12B.
HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation
TL;DR: Taking together, HSP27 alleviated cardiac aging and this action involved antioxidation and mitophagy activation, suggesting thatMitophagy was activated in old Tg hearts.
Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction.
Min Fan,Kun Yang,Xiaohui Wang,Xiaohui Wang,Yana Wang,Fei Tu,Tuanzhu Ha,Li Liu,David L. Williams,Chuanfu Li +9 more
TL;DR: It is demonstrated that endothelial HSPA12B is a target and coactivator for YAP/TEAD4 and cooperates with YAP to regulate endothelial angiogenesis after MI.
26