Yan Zhou
Chongqing Medical University
24 Papers
102 Citations
Yan Zhou is an academic researcher from Chongqing Medical University. The author has contributed to research in topics: Allele frequency & Genotype. The author has an hindex of 16, co-authored 24 publications.
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Papers
Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3
Shengping Hou,Liping Du,Bo Lei,Chi Pui Pang,Meifen Zhang,Wenjuan Zhuang,Minglian Zhang,Lulin Huang,Bo Gong,Meilin Wang,Qi Zhang,Ke Hu,Qingyun Zhou,Jian Qi,Chaokui Wang,Yuan Tian,Zi Ye,Liang Liang,Hongsong Yu,Hong Li,Yan Zhou,Qingfeng Cao,Yunjia Liu,Lin Bai,Dan Liao,Aize Kijlstra,Jianfeng Xu,Zhenglin Yang,Peizeng Yang +28 more
TL;DR: The risk G allele of rs117633859 in the promoter region of IL23R exhibited low transcriptional activation in a cell-based reporter assay and was associated with diminishedIL23R mRNA expression in human peripheral blood mononuclear cells.
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TNFAIP3 gene polymorphisms confer risk for Behcet’s disease in a Chinese Han population
Hong Li,Qing Liu,Shengping Hou,Liping Du,Qingyun Zhou,Yan Zhou,Aize Kijlstra,Zheng Li,Peizeng Yang +8 more
TL;DR: This study identified one strong risk SNP rs9494885 and two weak risk SNPs rs10499194 and rs7753873 of TNFAIP3 in Chinese Han BD patients.
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A functional variant of pre-miRNA-196a2 confers risk for Behcet’s disease but not for Vogt–Koyanagi–Harada syndrome or AAU in ankylosing spondylitis
Jian Qi,Shengping Hou,Qi Zhang,Dan Liao,Lin Wei,Jing Fang,Yan Zhou,Aize Kijlstra,Peizeng Yang +8 more
TL;DR: It is shown that a functional variant of miR-196a2 confers risk for Behcet’s disease but not for VKH syndrome or AAU+AS+ by modulating the miR -196a gene expression and by regulating pro-inflammatory IL-1β and MCP-1 production.
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Berberine suppresses Th17 and dendritic cell responses.
TL;DR: Findings suggest that the inhibitory effect of BBR on the Th17 response was mediated by a direct action on T cells as well as an indirect effect via DCs.
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Genetic Variations of IL17F and IL23A Show Associations with Behçet’s Disease and Vogt-Koyanagi-Harada Syndrome
Shengping Hou,Dan Liao,Jun Zhang,Jing Fang,Lu Chen,Jian Qi,Qi Zhang,Yunjia Liu,Lin Bai,Yan Zhou,Aize Kijlstra,Peizeng Yang +11 more
TL;DR: High gene copy numbers of IL17F and IL23A were associated with BD and VKH syndrome and enhancedIL17F protein production and PBMC proliferation wereassociated with high IL17f copy numbers.
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