Yan Zhao
Hokkaido University
46 Papers
365 Citations
Yan Zhao is an academic researcher from Hokkaido University. The author has contributed to research in topics: Pimonidazole & Annexin A5. The author has an hindex of 15, co-authored 46 publications.
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Papers
Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage.
Atsushi Yamashita,Yan Zhao,Yunosuke Matsuura,Kazuaki Yamasaki,Sayaka Moriguchi-Goto,Chihiro Sugita,Takashi Iwakiri,Nozomi Okuyama,Chihiro Koshimoto,Keiichi Kawai,Nagara Tamaki,Songji Zhao,Yuji Kuge,Yujiro Asada +13 more
TL;DR: Infiltrative macrophage in atherosclerotic arteries might affect metabolic systems, and hypoxia but not classical activation might augment glycolytic and pentose phosphate pathways in macrophages.
Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE−/− mice
Yan Zhao,Yuji Kuge,Yuji Kuge,Songji Zhao,Koichi Morita,Masayuki Inubushi,H. William Strauss,Francis G. Blankenberg,Nagara Tamaki +8 more
TL;DR: The higher absolute uptake levels of 18F-FDG may be advantageous for lesion detection, whereas the preferential uptake of 99mTc-annexin A5 in advanced lesions may be a useful indicator of late-stage lesions or vulnerable plaque transformation.
Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques
Yuji Kuge,Yuji Kuge,Nozomi Takai,Yuki Ogawa,Takashi Temma,Yan Zhao,Kantaro Nishigori,Seigo Ishino,Junko Kamihashi,Yasushi Kiyono,Yasushi Kiyono,Masashi Shiomi,Hideo Saji +12 more
TL;DR: Nuclear imaging with 99mTc-MT1-MMP mAb, in combination with CT and MRI, could provide new diagnostic imaging capabilities for detecting vulnerable plaques, although further investigations to improve target to blood ratios are strongly required.
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Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma.
Masahiro Murakami,Songji Zhao,Yan Zhao,Nusrat Fatema Chowdhury,Wenwen Yu,Ken-ichi Nishijima,Mitsuyoshi Takiguchi,Nagara Tamaki,Yuji Kuge +8 more
TL;DR: The sequential histological evaluation of the tumor microenvironment clarified tumor starvation in A498 xenografts treated with sorafenib and 18F-FMISO hypoxia imaging confirmed the tumor starvation.
Abstract 280: Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage
Atsushi Yamashita,Yan Zhao,Yunosuke Matsuura,Kazuaki Yamasaki,Sayaka Moriguchi-Goto,Takashi Iwakiri,Nozomi Okuyama,Chihiro Koshimoto,Keiichi Kawai,Nagara Tamaki,Songji Zhao,Yuji Kuge,Yujiro Asada +12 more
TL;DR: In this article, the authors identify changes in metabolic systems relative to glucose uptake and hypoxia in rabbit atherosclerotic arteries and cultured macrophages and evaluate comprehensive arterial and macrophage metabolism by performing metabolomic analyses using capillary electrophoresis-time of flight mass spectrometry.
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