Yan Zhang
Fudan University
11 Papers
96 Citations
Yan Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Innate immune system. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Yan Zhang include Fudan University Shanghai Medical College.
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Papers
SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1α–Dependent Glycolysis
Guangwei Liu,Yujing Bi,Bo Shen,Hui Yang,Yan Zhang,Xiao Wang,Huanrong Liu,Yun Lu,Jiongbo Liao,Xi Chen,Yiwei Chu +10 more
TL;DR: It is found that SIRT1 deficiency in MDSCs directs a specific switch to M1 lineage when cells enter the periphery from bone marrow, decreasing the suppressive function in favor of a proinflammatory M1 phenotype associated with tumor cell attack.
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Modulation of TSC-mTOR signaling on immune cells in immunity and autoimmunity.
TL;DR: The function of TSC1/2–mTOR to direct the innate and adaptive immune cell development and function is discussed and the role of MTOR signaling pathway in immune cell mediated diseases, especially autoimmunity is focused on.
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mTOR limits the recruitment of CD11b+Gr1+Ly6Chigh myeloid‐derived suppressor cells in protecting against murine immunological hepatic injury
Yan Zhang,Yujing Bi,Hui Yang,Xi Chen,Huanrong Liu,Yun Lu,Zhengguo Zhang,Jiongbo Liao,Shan Yang,Yiwei Chu,Ruifu Yang,Guangwei Liu +11 more
TL;DR: In this paper, the mTOR pathway integrates diverse environmental inputs, including immune signals and metabolic cues, to direct the innate and adaptive immune responses, and mTOR signaling is a pivotal negative determinant of MDSC recruitment in IMH disease.
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Targeting S1P1 Receptor Protects against Murine Immunological Hepatic Injury through Myeloid-Derived Suppressor Cells
Guangwei Liu,Yujing Bi,Ruoning Wang,Ruoning Wang,Hui Yang,Yan Zhang,Xiao Wang,Huanrong Liu,Yun Lu,Zhengguo Zhang,Wanna Chen,Yiwei Chu,Ruifu Yang +12 more
TL;DR: MDSCs are identified as an essential component that provides protection against IMH following FTY720 or rapamycin treatment, validating the S1P1–mTOR signaling axis as a potential therapeutic target in hepatic injury.
SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1a-
Guangwei Liu,Yujing Bi,Bo Shen,Hui Yang,Yan Zhang,Xiao Wang,Huanrong Liu,Yun Lu,Jiongbo Liao,Xi Chen,Yiwei Chu +10 more
- 01 Jan 2013
TL;DR: It is found that SIRT1 deficiency in MDSCs directs a specific switch to M1 lineage when cells enter the periphery from bone marrow, decreasing the suppressive function in favor of a proinflammatory M1 phenotype associated with tumor cell attack.
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