4 Papers
41 Citations
Yan Yu is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Innate immune system & Cell adhesion molecule. The author has an hindex of 2, co-authored 3 publications.
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Papers
Simultaneous tether extraction contributes to neutrophil rolling stabilization: a model study.
Yan Yu,Jin-Yu Shao +1 more
TL;DR: In this article, the authors present a two-dimensional neutrophil-rolling model to investigate whether and how membrane tethers contribute to stable neutrophin rolling. But their model assumes that neutrophils are rigid spheres covered with randomly distributed deformable microvilli, and endothelial cells are modeled as flat membrane surfaces decorated with evenly distributed ligands.
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A model for CD2/CD58-mediated adhesion strengthening
TL;DR: A theoretical model that simulates the accumulation of CD2 and CD58 in the contact area of a Jurkat T lymphoblast and a CD58-containing substrate and results are in reasonable agreement with the experimental observations.
14
From Surface Protrusion to Tether Extraction: A Mechanistic Model.
TL;DR: A two-scale (cellular and molecular) model of cellular deformation because of a point pulling force is established and illustrated how surface protrusion makes the transition to tether extraction, either gradually or abruptly.
2
Immobile Ligands Enhance FcγR-TLR2/1 Crosstalk by Promoting Interface Overlap of Receptor Clusters.
TL;DR: In this article , the inflammatory response of macrophages from FcγR-TLR2/1 crosstalk inversely depends on the ligand mobility within a model pathogen membrane.