Yan Yang

TL;DR: It is shown that the E3 ubiquitin ligase RNF5 interacted with MITA in a viral-infection-dependent manner and found that virus-induced ubiquitination and degradation of MITA by R NF5 occurred at the mitochondria.

TL;DR: It is suggested that WWP2 negatively regulates TLR3-mediated innate immune and inflammatory responses by targeting TRIF for ubiquitination and degradation.

TL;DR: This work identifies the human cytomegalovirus protein UL31 as an inhibitor of cGAS, a cytosolic DNA sensor that recognizes viral DNA and synthesizes the second messenger cGAMP upon viral infection and highlights the importance of this innate immune sensor in the host response to HCMV.

TL;DR: An endoplasmic reticulum stress-inducing cyclometalated Ir(III)-bisNHC complex (1a) is reported as a new ICD inducer, and based on this compound, a clickable photoaffinity probe was designed for target identification, which unveiled the engagement of the master regulator protein BiP of the unfolded protein response pathway.