Yan Yang
Université de Montréal
4 Papers
Yan Yang is an academic researcher from Université de Montréal. The author has contributed to research in topics: Gene & Genetic association. The author has an hindex of 4, co-authored 4 publications.
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Papers
Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation.
Fadi F. Hamdan,Julie Gauthier,Dan Spiegelman,Anne Noreau,Yan Yang,Stéphanie Pellerin,Sylvia Dobrzeniecka,Mélanie Côté,Elizabeth Perreau-Linck,Lionel Carmant,Guy D'Anjou,Eric Fombonne,Anjené M. Addington,Judith L. Rapoport,Lynn E. DeLisi,Marie-Odile Krebs,Fayçal Mouaffak,Ridha Joober,Laurent Mottron,Pierre Drapeau,Claude Marineau,Ronald G. Lafrenière,Jean-Claude Lacaille,Guy A. Rouleau,Jacques L. Michaud +24 more
TL;DR: The results indicate that SYNGAP1 disruption is a cause of autosomal dominant nonsyndromic mental retardation.
A population genetic approach to mapping neurological disorder genes using deep resequencing
Rachel A. Myers,Ferran Casals,Julie Gauthier,Fadi F. Hamdan,Jon Keebler,Jon Keebler,Adam R. Boyko,Carlos Bustamante,Amélie Piton,Dan Spiegelman,Edouard Henrion,Martine Zilversmit,Julie Hussin,Jacklyn Quinlan,Yan Yang,Ronald G. Lafrenière,Alexander R. Griffing,Eric A. Stone,Guy A. Rouleau,Philip Awadalla +19 more
TL;DR: This study demonstrates that genes associated with complex disorders can be mapped using resequencing and analytical methods with sample sizes far smaller than those required by genome-wide association studies and supports the hypothesis that rare mutations account for a proportion of the phenotypic variance of these complex disorders.
Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
Amélie Piton,Julie Gauthier,Fadi F. Hamdan,Ronald G. Lafrenière,Yan Yang,Edouard Henrion,Sandra Laurent,Anne Noreau,Pascale Thibodeau,Liliane Karemera,Dan Spiegelman,Kuku F,Duguay J,Laurie Destroismaisons,Jolivet P,Mélanie Côté,Lachapelle K,Ousmane Diallo,A Raymond,Claude Marineau,Nathalie Champagne,Lan Xiong,Claudia Gaspar,Jean-Baptiste Rivière,Julien Tarabeux,Patrick Cossette,Marie-Odile Krebs,Marie-Odile Krebs,Judith L. Rapoport,Anjené M. Addington,Lynn E. DeLisi,Lynn E. DeLisi,Laurent Mottron,Ridha Joober,Eric Fombonne,Pierre Drapeau,Guy A. Rouleau +36 more
TL;DR: Test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions in a fraction of cases, and identified >200 non-synonymous variants, with an excess of rare damaging variants, which suggest the presence of disease-causing mutations.
Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts
Philip Awadalla,Julie Gauthier,Rachel A. Myers,Rachel A. Myers,Ferran Casals,Fadi F. Hamdan,Alexander R. Griffing,Mélanie Côté,Edouard Henrion,Dan Spiegelman,Julien Tarabeux,Amélie Piton,Yan Yang,Adam R. Boyko,Carlos Bustamante,Lan Xiong,Judith L. Rapoport,Anjené M. Addington,J. Lynn E. DeLisi,Marie-Odile Krebs,Ridha Joober,Bruno Millet,Eric Fombonne,Laurent Mottron,Martine Zilversmit,Jon Keebler,Jon Keebler,Hussein Daoud,Claude Marineau,Marie-Hélène Roy-Gagnon,Marie-Pierre Dubé,Adam Eyre-Walker,Pierre Drapeau,Eric A. Stone,Ronald G. Lafrenière,Guy A. Rouleau +35 more
TL;DR: A direct measure of the de novo mutation rate and selective constraints from DNMs estimated from a deep resequencing data set generated from a large cohort of ASD and SCZ cases and population control individuals with available parental DNA is presented.