Yan Yan
Jiangnan University
14 Papers
68 Citations
Yan Yan is an academic researcher from Jiangnan University. The author has contributed to research in topics: Immune system & Chemokine. The author has an hindex of 6, co-authored 14 publications. Previous affiliations of Yan Yan include Chinese Academy of Sciences.
Chat about Author
Papers
CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention.
TL;DR: The impacts of CCL19 and CCR7 expression on the regulation of viral pathogenesis with an emphasis on the corresponding signaling pathways and adjuvant mechanisms are summarized.
CCL19 and CCL28 Augment Mucosal and Systemic Immune Responses to HIV-1 gp140 by Mobilizing Responsive Immunocytes into Secondary Lymph Nodes and Mucosal Tissue
Kai Hu,Sukun Luo,Lina Tong,Xin Huang,Wei Jin,Wenjie Huang,Tao Du,Yan Yan,Siyi He,George E. Griffin,Robin J. Shattock,Qinxue Hu,Qinxue Hu +12 more
TL;DR: PCCL19 and pCCL28 can enhance HIV-1 envelope–specific systemic and mucosal Ab responses, as well as T cell responses, and such enhancements appear to be associated with mobilization of responsive immunocytes into secondary lymphoid organs and mucosa tissues through interactions with corresponding receptors.
49
HSV-2 Immediate-Early Protein US1 Inhibits IFN-β Production by Suppressing Association of IRF-3 with IFN-β Promoter
Mudan Zhang,Yalan Liu,Ping Wang,Xinmeng Guan,Siyi He,Sukun Luo,Chang Li,Kai Hu,Wei Jin,Tao Du,Yan Yan,Zhenfeng Zhang,Zhenhua Zheng,Hanzhong Wang,Qinxue Hu,Qinxue Hu +15 more
TL;DR: It is demonstrated that productive HSV-2 infection suppresses Sendai virus (SeV) or polyinosinic-polycytidylic acid-induced IFN-β production, and it is revealed that US1, an immediate-early protein of HSv-2, contributes to such suppression, demonstrating an unconventional strategy exploited by a dsDNA virus to interrupt type I IFN signaling pathway.
40
Immunization with HSV-2 gB-CCL19 Fusion Constructs Protects Mice against Lethal Vaginal Challenge
Yan Yan,Kai Hu,Xu Deng,Xinmeng Guan,Sukun Luo,Lina Tong,Tao Du,Ming Fu,Mudan Zhang,Yalan Liu,Qinxue Hu +10 more
TL;DR: These findings indicate that enhanced humoral and cellular immune responses can be achieved by immunization with an immunogen fused to a chemokine, providing information for the design of vaccines against mucosal infection by HSV-2 and other sexually transmitted viruses.
16
Evaluation of Epstein-Barr Virus Salivary Shedding in HIV/AIDS Patients and HAART Use: A Retrospective Cohort Study
Yan Yan,Ren Yong,Chen Renfang,Jing Hu,Yongjia Ji,Junyang Yang,Jiayin Shen,Lvyin Hu,Hao Pei,Jun Wang,Yuanwang Qiu,Hongzhou Lu,Lihua Huang +12 more
TL;DR: HAART use is beneficial in decreasing the EBV salivary shedding in HIV/AIDS patients and indirectly decreases EBV transmission risk, according to a retrospective cohort study of EBV serological tests for patients in China.
15