Yan Xu
Hunan University
5 Papers
Yan Xu is an academic researcher from Hunan University. The author has contributed to research in topics: Innate immune system & Interferon. The author has an hindex of 4, co-authored 5 publications.
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Papers
TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS.
Binbin Xue,Huiyi Li,Mengmeng Guo,Jingjing Wang,Yan Xu,Xuan Zou,Rilin Deng,Guangdi Li,Haizhen Zhu +8 more
TL;DR: A novel mechanism by which TRIM21 promotes the K27-linked polyubiquitination of MAVS to positively regulate innate immune response, thereby inhibiting viral infection is revealed.
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ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway.
Binbin Xue,Darong Yang,Jingjing Wang,Yan Xu,Xiaohong Wang,Yuwen Qin,Renyun Tian,Shengwen Chen,Qinya Xie,Nianli Liu,Haizhen Zhu +10 more
TL;DR: The present study shows a novel antiviral mechanism of ISGs and elucidated that ISG12a recruits an E3 ligase, SKP2, for ubiquitination and degradation of viral protein and restricts viral infection.
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Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5.
Qinya Xie,Shengwen Chen,Renyun Tian,Xiang Huang,Rilin Deng,Binbin Xue,Yuwen Qin,Yan Xu,Jingjing Wang,Mengmeng Guo,Jinwen Chen,Songqing Tang,Guangdi Li,Haizhen Zhu +13 more
TL;DR: It is found that MDA5 can suppress hepatitis C virus (HCV) replication independently of IFN signaling through its C-terminal-deficient domain bound to viral RNA, in which lncITPRIP-1 plays a role as an assistant.
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The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway
Rilin Deng,Chaohui Zuo,Yongqi Li,Binbin Xue,Zhen Xun,Yanxia Guo,Xiaohong Wang,Yan Xu,Renyun Tian,Shengwen Chen,Qian Liu,Jinwen Chen,Jingjing Wang,Xiang Huang,Huiyi Li,Mengmeng Guo,Xintao Wang,Miaomiao Yang,Zhihui Wu,Jinfeng Wang,Jiahuan Ma,Jun Hu,Guangdi Li,Songqing Tang,Zhengkun Tu,Hongbin Ji,Hongbin Ji,Haizhen Zhu,Haizhen Zhu +28 more
TL;DR: A mechanism underlying the anticancer effects of IFN is revealed, as represented by ISG12a, and the identified interrelations among innate immunity, Wnt/β-catenin signaling, and cancer immunity may provide new insight into strategies that will improve the efficiency of immunotherapy.
IRF1 Promotes the Innate Immune Response to Viral Infection by Enhancing the Activation of IRF3.
Jingjing Wang,Huiyi Li,Binbin Xue,Rilin Deng,Xiang Huang,Yan Xu,Shengwen Chen,Renyun Tian,Xintao Wang,Zhen Xun,Ming Sang,Haizhen Zhu +11 more
TL;DR: Overall, this study reveals a novel mechanism by which IRF1 promotes the innate immune response to viral infection by enhancing the activation of IRF3, thereby inhibiting viral infection.
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