Yan Wen
Fudan University
11 Papers
Yan Wen is an academic researcher from Fudan University. The author has contributed to research in topics: Ganglionic eminence & Subventricular zone. The author has an hindex of 7, co-authored 11 publications. Previous affiliations of Yan Wen include Boston Children's Hospital.
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Papers
Sp8 and Sp9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression
Zhejun Xu,Qifei Liang,Xiaolei Song,Zhuangzhi Zhang,Susan Lindtner,Zhenmeiyu Li,Yan Wen,Guoping Liu,Teng Guo,Dashi Qi,Min Wang,Chunyang Wang,Hao Li,Yan You,Xin Wang,Bin Chen,Hua Feng,John L.R. Rubenstein,Zhengang Yang +18 more
TL;DR: Conditional deletion of Sp8, Sp9 and Six3 reveals a regionally specific transcription pathway that selectively drives the generation of striatal DRD2-expressing medium spiny neurons in mouse striatum.
The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons.
Yan Wen,Zhuangzhi Zhang,Zhenmeiyu Li,Guoping Liu,Guangxu Tao,Xiaolei Song,Zhejun Xu,Zicong Shang,Teng Guo,Zihao Su,Haotian Chen,Yan You,Jiada Li,Zhengang Yang +13 more
TL;DR: It is demonstrated that PROK2/PROKR2 signaling is crucial for the tangential and radial migration of OB interneurons in the SVZ‐RMS‐OB.
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Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.
Teng Guo,Guoping Liu,Heng Du,Yan Wen,Song Wei,Zhenmeiyu Li,Guangxu Tao,Zicong Shang,Xiaolei Song,Zhuangzhi Zhang,Zhejun Xu,Yan You,Bin Chen,John L.R. Rubenstein,Zhengang Yang +14 more
TL;DR: It is proposed that DLX1/2 promote OB interneuron development mainly through activating the expression of Sp8/9, which further promote Tshz1 and Prokr2 expression.
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Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration.
Guangxu Tao,Zhenmeiyu Li,Yan Wen,Xiaolei Song,Song Wei,Heng Du,Zhengang Yang,Zhejun Xu,Yan You +8 more
TL;DR: It is provided evidence that Sp8/Sp9 activity is required for normal MGE-derived cortical interneuron migration, at least in part, through regulating the expression of EphA3, Ppp2r2c, and Rasgef1b.
Transcriptional Profiling Reveals the Transcription Factor Networks Regulating the Survival of Striatal Neurons
Lin Yang,Zihao Su,Xiaolei Song,Zhenmeiyu Li,Ziwu Wang,Haotian Chen,Zicong Shang,Heng Du,Yan Wen,Guoping Liu,Dashi Qi,Xiaosu Li,Yan You,Zhejun Xu,Zhuangzhi Zhang +14 more
TL;DR: A comprehensive temporal transcriptome atlas of the mouse striatum at multiple developmental stages is presented and the hub TFs Six3 and Meis2 which are involved in regulating the apoptosis of striatal neurons are identified.
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