Yan Wang
Harbin Medical University
7 Papers
1 Citations
Yan Wang is an academic researcher from Harbin Medical University. The author has contributed to research in topics: SIRT3 & Mitochondrion. The author has an hindex of 5, co-authored 7 publications.
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Papers
Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Yu Sun,Fanghao Lu,Xiangjing Yu,Bingzhu Wang,Jian Chen,Fangping Lu,Shuo Peng,Xiaojiao Sun,Miao Yu,He Chen,Yan Wang,Linxue Zhang,Ning Liu,Haining Du,Dechao Zhao,Weihua Zhang +15 more
TL;DR: It is found that exogenous H2S could improve cardiac functions, reduce mitochondrial fragments and ROS levels, enhance mitochondrial respiration chain activities and inhibit mitochondrial apoptosis in the hearts of db/db mice.
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Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice
Yu Sun,Zhiliang Tian,Ning Liu,Linxue Zhang,Zhaopeng Gao,Xiaojiao Sun,Miao Yu,Jichao Wu,Fan Yang,Yajun Zhao,Huan Ren,He Chen,Dechao Zhao,Yan Wang,Shiyun Dong,Changqing Xu,Fanghao Lu,Weihua Zhang +17 more
TL;DR: H2S regulated the acetylation level and activities of enzymes in fatty acid oxidation and glucose oxidation in cardiac tissues of db/db mice and suggested that H2S induced a switch in cardiac energy substrate utilization in DCM through regulating SIRT3 pathway.
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Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice
Yu Sun,Zongyan Teng,Xiaojiao Sun,Linxue Zhang,Jian Chen,Bingzhu Wang,Fangping Lu,Ning Liu,Miao Yu,Shuo Peng,Yan Wang,Dechao Zhao,Yajun Zhao,Huan Ren,Zhongyi Cheng,Shiyun Dong,Fanghao Lu,Weihua Zhang +17 more
TL;DR: It is concluded that exogenous H2S plays a critical role in improving cardiac mitochondrial function in diabetes by upregulating SIRT3.
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Exogenous H2S modulates mitochondrial fusion–fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state
Aili Sun,Yan Wang,Jiaqi Liu,Xiangjing Yu,Yu Sun,Fan Yang,Shiyun Dong,Jichao Wu,Yajun Zhao,Changqing Xu,Fanghao Lu,Weihua Zhang +11 more
TL;DR: It is demonstrated that H2S inhibits VSMC proliferation through regulating mitochondrial fission and aids in inhibiting mitochondrial fragmentation and affects proliferation in db/db mice and HPASMCs by decreasing Drp 1 expression.
Exogenous H2S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts.
Miao Yu,Haining Du,Bingzhu Wang,Jian Chen,Fangping Lu,Shuo Peng,Yu Sun,Ning Liu,Xiaojiao Sun,Dong Shiyun,Yajun Zhao,Yan Wang,Dechao Zhao,Fanghao Lu,Weihua Zhang +14 more
TL;DR: It is suggested that H2S regulates VAMP3 ubiquitylation via Hrd1 S-sulfhydration at Cys115 to prevent CD36 translocation in diabetes.
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