5 Papers
92 Citations
Yan Wang is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & G protein-coupled receptor. The author has an hindex of 4, co-authored 5 publications.
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Papers
Regulation of CFTR channels by HCO(3)--sensitive soluble adenylyl cyclase in human airway epithelial cells.
TL;DR: The findings demonstrate that sAC signaling pathway is involved in the regulation of CFTR function in human airway epithelium and thereby provides a link between the level of intracellular H CO(3)(-)/CO(2) and the modulation of HCO( 3)(-)-conductiveCFTR function by cAMP/PKA.
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A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors
Ying Sun,Yuanyuan Duan,Anna Eisenstein,Wenbao Hu,Adrien Quintana,Wai Kwan Lam,Yan Wang,Zhenguo Wu,Katya Ravid,Pingbo Huang +9 more
TL;DR: The results show that the A2BAR inhibits NF&kgr;B activation by physically interacting with p105, thereby blocking its polyubiquitylation and degradation.
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Keratin K18 increases cystic fibrosis transmembrane conductance regulator (CFTR) surface expression by binding to its C-terminal hydrophobic patch.
Yuanyuan Duan,Ying Sun,Fan Zhang,Wei Kevin Zhang,Dong Wang,Yan Wang,Xu Cao,Wenbao Hu,Changyan Xie,John Cuppoletti,Thomas M. Magin,Haixia Wang,Zhenguo Wu,Ning Li,Pingbo Huang +14 more
TL;DR: K18 binding increased the surface expression of CFTR by accelerating its apical recycling rate without altering CFTR biosynthesis, maturation, or internalization, and suggest that K18 and its dimerization partner, K8, may be modifier genes in cystic fibrosis.
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Functional coupling of Gs and CFTR is independent of their association with lipid rafts in epithelial cells.
TL;DR: The data suggest that G PCR-mediated signaling maintain their integrity after lipid raft disruption in Calu-3 and T84 epithelial cells and cast doubts on the role of lipid rafts as signaling platforms in GPCR- mediated signaling.
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Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia
Changyan Xie,Xu Cao,Xibing Chen,Dong Wang,Wei Kevin Zhang,Ying Sun,Wenbao Hu,Zijing Zhou,Yan Wang,Pingbo Huang +9 more
TL;DR: It is shown that the channel activity of both WT and G551D CFTR is directly stimulated by mechanical perturbation induced by cell swelling at the single‐channel, cellular, and tissue levels, and suggested that the mechanosensitivity of G551d CFTR might underlie the mild phenotypes resulting from this mutation.
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