Yan V. Sun
Emory University
227 Papers
857 Citations
Yan V. Sun is an academic researcher from Emory University. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 43, co-authored 177 publications. Previous affiliations of Yan V. Sun include Vanderbilt University & Yale University.
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Papers
A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality
Anurag Verma,Jessica Minnier,Emily S. Wan,Jennifer E. Huffman,Lina Gao,Jacob Joseph,Yuk-Lam Ho,Wen-Chih Wu,Kelly Cho,Bryan L. Gorman,Nallakkandi Rajeevan,Saiju Pyarajan,Helene Garcon,James B. Meigs,Yan V. Sun,Peter D. Reaven,John E. McGeary,A. Suzuki,Joel Gelernter,Julie Lynch,Jeffrey M Peterson,Seyedeh M. Zekavat,Pradeep Natarajan,Sharvari Dalal,Darshana Jhala,Mehrdad Arjomandi,Elise Gatsby,Kristine E. Lynch,Robert A. Bonomo,Mathew S. Freiberg,Gita A. Pathak,Jin Zhou,Curtis J. Donskey,R. Madduri,Quinn S. Wells,Rose D L Huang,Renato Polimanti,Kyong-Mi Chang,Katherine P. Liao,Philip S. Tsao,Peter W.F. Wilson,Adriana M. Hung,Christopher J. O'Donnell,John Michael Gaziano,Richard L. Hauger,Sudha K. Iyengar,Shiuh Wen Luoh +46 more
TL;DR: The MUC5B variant rs35705950-T may confer protection in COVID-19 hospitalizations and among MVP individuals of European ancestry, it was associated with fewer post-CO VID-19 pneumonia events.
A large-scale multi-ethnic genome-wide association study of coronary artery disease
Themistocles L. Assimes,Catherine Tcheandjieu,Xiang Zhu,Austin T. Hilliard,Shoa L. Clarke,Valerio Napolioni,Shining Ma,Huaying Fang,Bryan R Gorman,Kyung Min Lee,Fei Chen,Saiju Pyarajan,Rebecca J Song,Mary Plomondon,Thomas Maddox,Stephen Waldo,Nasa Sinnott-Armstrong,Yuk-Lam Ho,Genevieve L. Wojcik,Steven Buyske,Charles Kooperberg,Jeffrey Haessler,Ruth J. F. Loos,Ron Do,Marie Verbanck,Kumardeep Chaudhary,Kari E. North,Christy L. Avery,Christopher A. Haiman,Loic Le Marchand,Lynne R. Wilkens,Joshua C. Bis,Hampton L. Leonard,Botong Shen,Leslie A. Lange,Ayush Giri,Yingchang Lu,Ozan Dikilitas,Iftikhar J. Kullo,Ian B. Stanaway,Gail P. Jarvik,Adam S. Gordon,Scott J. Hebbring,Bahram Namjou,Kenneth M. Kaufman,Satoshi Koyama,Kaoru Ito,Kazuyoshi Ishigaki,Yoichiro Kamatani,Noah Tsao,Shefali S. Verma,Marylyn D. Ritchie,Rachel L. Kember,Aris Baras,Luca A. Lotta,Pradeep Natarajan,Michael G. Levin,Elizabeth R. Hauser,Donald R. Miller,Marijana Vujkovic,Jennifer E. Huffman,Sridharan Raghavan,Derek Klarin,Jennifer Lee,Benjamin F. Voight,Daniel J. Rader,Kyong-Mi Chang,Scott M. Damrauer,Julie Lynch,Peter W.F. Wilson,Hua Tang,Yan V. Sun,P.S. Tsao,Christopher P. O'Donnell,Sekar Kathiresan,Danish Saleheen,J. Michael Gaziano,Peter D. Reaven,Kelly Cho,Alexander G. Bick,Mariaelisa Graff,Jie Huang +81 more
- 10 Mar 2021
TL;DR: A multi-ethnic genome-wide association study of CAD involving nearly a quarter of a million cases, incorporating the largest cohorts to date of Whites, Blacks, and Hispanics from the Million Veteran Program with existing studies including CARDIoGRAMplusC4D, UK Biobank, and Biobanks Japan is reported.
Association of interleukin 6 receptor variant with cardiovascular disease effects of interleukin 6 receptor blocking therapy: A phenome - Wide association study
Tianxi Cai,Tianxi Cai,Yichi Zhang,Yichi Zhang,Yuk Lam Ho,Nicholas Link,Jiehuan Sun,Jiehuan Sun,Jie Huang,Jie Huang,Tianrun Cai,Tianrun Cai,Scott M. Damrauer,Yuri Ahuja,Jacqueline Honerlaw,Lauren Costa,Petra Schubert,Chuan Hong,David R. Gagnon,David R. Gagnon,Yan V. Sun,Yan V. Sun,J. Michael Gaziano,J. Michael Gaziano,Peter W.F. Wilson,Kelly Cho,Kelly Cho,Kelly Cho,Philip S. Tsao,Philip S. Tsao,Christopher J. O'Donnell,Christopher J. O'Donnell,Christopher J. O'Donnell,Katherine P. Liao,Katherine P. Liao,Michael Gaziano,Rachel Ramoni,Jim Breeling,Kyong-Mi Chang,Grant D. Huang,Sumitra Muralidhar,Philip S. Tsao,Jennifer Moser,Stacey B. Whitbourne,Jessica V. Brewer,Jessica V. Brewer,John Concato,Stuart R. Warren,Dean P. Argyres,Brady Stephens,Mary Brophy,Donald E. Humphries,Nhan Do,Shahpoor Shayan,Xuan-Mai T. Nguyen,Saiju Pyarajan,Elizabeth R. Hauser,Hongyu Zhao,Rachel McArdle,Louis J. Dell’Italia,John B. Harley,Jeff Whittle,Jean C. Beckham,John M. Wells,Salvador Gutierrez,Gretchen Gibson,Laurence Kaminsky,Gerardo Villareal,Junzhe Xu,Mark B. Hamner,Kathlyn Sue Haddock,Sujata Bhushan,Pran Iruvanti,Michael Godschalk,Zuhair Ballas,Malcolm Buford,Stephen Mastorides,Jon B. Klein,Nora R. Ratcliffe,Hermes Florez,Alan Swann,Maureen Murdoch,P. S. Sriram,Scott Kinlay,Shing Shing Yeh,Ronald G Washburn,D Jhala,Samuel M. Aguayo,David M. Cohen,Satish C. Sharma,John J. Callaghan,Krisann K. Oursler,Mary A. Whooley,Sunil K. Ahuja,Amparo Gutierrez,Ron B. Schifman,Jennifer Greco,Michael Rauchman,Richard J. Servatius,Mary E. Oehlert,Agnes Wallbom,Ronald Fernando,Timothy R. Morgan,Todd Stapley,Scott Sherman,Gwenevere Anderson,Elif Sonel,Edward Boyko,Laurence Meyer,Samir Gupta,Joseph Fayad,Adriana M. Hung,Jack H. Lichy,Robin A. Hurley,Brooks Robey,Rob Striker +115 more
TL;DR: The findings of an association of theIL6R SNP with reduced risk for aortic aneurysms correspond with the newest indication for IL6R blockade, giant cell arteritis, of which a major complication is aorto-aneurysm.
Identification of epistatic effects using a protein–protein interaction database
Yan V. Sun,Sharon L.R. Kardia +1 more
TL;DR: This study demonstrates that using PPI data can assist in targeting statistical hypothesis testing to biological plausible epistatic interaction that reflects molecular mechanisms.
Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study.
Ervin R. Fox,Solomon K. Musani,Maja Barbalić,Honghuang Lin,Bing Yu,Kofo O. Ogunyankin,Nicholas L. Smith,Abdullah Kutlar,Nicole L. Glazer,Wendy S. Post,Dina N. Paltoo,Daniel L. Dries,Deborah N. Farlow,Christine W. Duarte,Sharon L.R. Kardia,Kristin J. Meyers,Yan V. Sun,Donna K. Arnett,Amit Patki,Jin Sha,Xiangqui Cui,Tandaw E. Samdarshi,Alan D. Penman,Kirsten Bibbins-Domingo,Petra Bůžková,Emelia J. Benjamin,David A. Bluemke,Alanna C. Morrison,Gerardo Heiss,J. Jeffrey Carr,Russell P. Tracy,Thomas H. Mosley,Herman A. Taylor,Bruce M. Psaty,Susan R. Heckbert,Thomas P. Cappola,Ramachandran S. Vasan +36 more
TL;DR: In the largest genome-wide association study of cardiac structure and function to date in African Americans, it is suggested that 4 genetic loci related to left ventricular mass, interventricular septal wall thickness,left ventricular internal diastolic diameter, and ejection fraction may be unique to individuals of African ancestry.