Yan Shao
Southern Medical University
22 Papers
Yan Shao is an academic researcher from Southern Medical University. The author has contributed to research in topics: Medicine & Chondrocyte. The author has an hindex of 8, co-authored 11 publications.
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Papers
Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2.
Haiyan Zhang,Chuangxin Lin,Chun Zeng,Zhenyu Wang,Hua Wang,Jiansen Lu,Xin Liu,Yan Shao,Chang Zhao,Jianying Pan,Song Xu,Yue Zhang,Denghui Xie,Daozhang Cai,Xiaochun Bai +14 more
TL;DR: The results show that promoting the macrophage M1 polarisation leads to exacerbation of experimental OA partially through secretion of Rspo2 and activation of β-catenin signalling in chondrocytes.
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Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7
Haiyan Zhang,Yan Shao,Zihao Yao,Liangliang Liu,Hongbo Zhang,Jie Yin,Haoyu Xie,Kai Li,Pinglin Lai,Hua Zeng,Guozhi Xiao,Chun Zeng,Daozhang Cai,Xiaochun Bai +13 more
TL;DR: FBXW7 is a key factor in the association between mechanical overloading and chondrocyte senescence and cartilage ageing in the pathology of OA, and inhibition of JNK activity by DTP3, a MKK7 inhibitor, ameliorated chondROcytesenescenceand cartilage degeneration.
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Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice.
Jiansen Lu,Haiyan Zhang,Daozhang Cai,Chun Zeng,Pinglin Lai,Yan Shao,Hang Fang,Delong Li,Jiayao Ouyang,Chang Zhao,Denghui Xie,Bin Huang,Jian Yang,Yu Jiang,Xiaochun Bai +14 more
TL;DR: A positive‐feedback regulation of H‐type vessel formation in subchondral bone by articular chondrocyte nutrient‐sensing mTORC1 signaling is essential for the pathogenesis and progression of OA.
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Hesperidin inhibits synovial cell inflammation and macrophage polarization through suppression of the PI3K/AKT pathway in complete Freund's adjuvant-induced arthritis in mice.
Weizhong Qi,Chuangxin Lin,Fan Kai,Ziyu Chen,Liangliang Liu,Xiaofeng Feng,Haiyan Zhang,Yan Shao,Hang Fang,Chang Zhao,Rongkai Zhang,Daozhang Cai +11 more
TL;DR: It is concluded that HSN has significant anti-inflammatory activities and reduces the potential of MMPs in rheumatoid arthritis and the degree of polarization of macrophages to M1.
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FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis
Dong Guo,Chuangxin Lin,Yuheng Lu,Hong Guan,Weizhong Qi,Hongbo Zhang,Yan Shao,Chun Zeng,Rongkai Zhang,Haiyan Zhang,Xiaochun Bai,Daozhang Cai +11 more
TL;DR: In this paper , Fatty acid-binding protein 4 (FABP4) was found upregulated in synovial M1-polarized macrophages in RA.
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