Yan Qin
Chinese Academy of Sciences
12 Papers
69 Citations
Yan Qin is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Protein family & Genome evolution. The author has an hindex of 7, co-authored 12 publications. Previous affiliations of Yan Qin include Boston Children's Hospital & Harvard University.
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Papers
A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System
Yan Qin,Brian S. Garrison,Wenjiang Ma,Wenjiang Ma,Rui Wang,Rui Wang,Ai-Ping Jiang,Ai-Ping Jiang,Jing Li,Jing Li,Meeta Mistry,Roderick T. Bronson,Daria Santoro,Daria Santoro,Charlotte Franco,Charlotte Franco,Daisy A. Robinton,Beth Stevens,Beth Stevens,Derrick J. Rossi,Derrick J. Rossi,Chafen Lu,Chafen Lu,Timothy A. Springer,Timothy A. Springer +24 more
TL;DR: It is shown that LRRC33 on the surface of microglia functions as a milieu molecule and enables highly localized, integrin-αVβ8-dependent TGF-β activation.
164
Conformational equilibria and intrinsic affinities define integrin activation.
Jing Li,Yang Su,Yang Su,Wei Xia,Wei Xia,Yan Qin,Yan Qin,Martin J. Humphries,Dietmar Vestweber,Carlos Cabañas,Chafen Lu,Chafen Lu,Timothy A. Springer +12 more
TL;DR: The results suggest new principles for regulating signaling in the large class of receptors built from extracellular domains in tandem with single‐span transmembrane domains with profound regulation of affinity.
134
Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells
Ai-Ping Jiang,Jin-Feng Jiang,Ji-Fu Wei,Ming-Gao Guo,Yan Qin,Qian-Qian Guo,Li Ma,Bao-Chi Liu,Xiaolei Wang,Ronald S. Veazey,Yong-Bing Ding,Jian-Hua Wang +11 more
TL;DR: The role of human mast cells isolated from mucosal tissues in mediating HIV-1 trans-infection of CD4+ T cells is demonstrated and will benefit the development of strategies to combat primary HIV- 1 dissemination.
36
LRRC33 is a novel binding and potential regulating protein of TGF-β1 function in human acute myeloid leukemia cells.
TL;DR: LRRC33 co-localizes and forms complex with latent TGF-β1 protein on the cell surface and intracellularly in these cells, and is expected to be a starting point of more comprehensive research on LRRC33 as novel T GF-β regulating protein and potential non-genomic based drug target for AML and other myeloid malignancy.
Production of hepatitis C virus lacking the envelope-encoding genes for single-cycle infection by providing homologous envelope proteins or vesicular stomatitis virus glycoproteins in trans.
TL;DR: Interestingly, it was found that vesicular stomatitis virus (VSV) glycoproteins could efficiently rescue the production of HCV lacking endogenous envelope proteins, which no longer required apolipoprotein E for virus production.