Yan Li
Pasteur Institute
13 Papers
10 Citations
Yan Li is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 9, co-authored 13 publications. Previous affiliations of Yan Li include French Institute of Health and Medical Research.
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Papers
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.
Ai Ing Lim,Ai Ing Lim,Ai Ing Lim,Yan Li,Yan Li,Silvia Lopez-Lastra,Silvia Lopez-Lastra,Silvia Lopez-Lastra,Ralph Stadhouders,Franziska Paul,Armanda Casrouge,Armanda Casrouge,Nicolas Serafini,Nicolas Serafini,Anne Puel,Anne Puel,Jacinta Bustamante,Jacinta Bustamante,Laura Surace,Laura Surace,Guillemette Masse-Ranson,Guillemette Masse-Ranson,Eyal David,Helene Strick-Marchand,Helene Strick-Marchand,Lionel Le Bourhis,Roberto Cocchi,Davide Topazio,Paolo Graziano,Lucia Anna Muscarella,Lars Rogge,Xavier Norel,Jean-Michel Sallenave,Matthieu Allez,Thomas Graf,Rudi W. Hendriks,Jean-Laurent Casanova,Ido Amit,Hans Yssel,James P. Di Santo,James P. Di Santo +40 more
TL;DR: The results support a model of tissue ILC differentiation ("ILC-poiesis"), whereby diverse ILC subsets are generated in situ from systemically distributed ILCPs in response to local environmental signals.
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A human immune system mouse model with robust lymph node development.
Yan Li,Yan Li,Guillemette Masse-Ranson,Guillemette Masse-Ranson,Zacarias Garcia,Zacarias Garcia,Timothée Bruel,Ayrin Kök,Ayrin Kök,Helene Strick-Marchand,Helene Strick-Marchand,Grégory Jouvion,Nicolas Serafini,Nicolas Serafini,Ai Ing Lim,Ai Ing Lim,Mathilde Dusséaux,Mathilde Dusséaux,Thierry Hieu,Thierry Hieu,Franck Bourgade,Antoine Toubert,Daniela Finke,Daniela Finke,Olivier Schwartz,Philippe Bousso,Philippe Bousso,Hugo Mouquet,Hugo Mouquet,James P. Di Santo,James P. Di Santo +30 more
TL;DR: An improved model that harbors lymph nodes and therefore permits investigation of local human adaptive immune processes in secondary lymphoid tissue is reported and it is demonstrated that LN TFH cells are targets of acute HIV infection and represent a reservoir for latent HIV.
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Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver
Mathilde Dusséaux,Mathilde Dusséaux,Guillemette Masse-Ranson,Guillemette Masse-Ranson,Sylvie Darche,Sylvie Darche,James Ahodantin,Yan Li,Yan Li,Oriane Fiquet,Oriane Fiquet,Elodie Beaumont,Pierrick Moreau,Lise Rivière,Christine Neuveut,Patrick Soussan,Philippe Roingeard,Dina Kremsdorf,James P. Di Santo,James P. Di Santo,Helene Strick-Marchand,Helene Strick-Marchand +21 more
TL;DR: HBV infection completes a full life cycle and recapitulates some of the immunopathology observed in patients with chronic infection and is found to infect liver progenitor cells, which could be involved in hepatocellular carcinogenesis.
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A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development.
Yan Li,Jean-Jacques Mention,Nathalie Court,Guillemette Masse-Ranson,Antoine Toubert,Hergen Spits,Nicolas Legrand,Erwan Corcuff,Helene Strick-Marchand,James P. Di Santo +9 more
TL;DR: A novel HIS model that compromises host myeloid cell development via deficiency in the receptor tyrosine kinase Flk2/Flt3 should provide a means to dissect human DC differentiation and represents a novel platform to screen immune adjuvants and DC targeting therapies.
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A functional DC cross talk promotes human ILC homeostasis in humanized mice.
Silvia Lopez-Lastra,Silvia Lopez-Lastra,Silvia Lopez-Lastra,Guillemette Masse-Ranson,Guillemette Masse-Ranson,Oriane Fiquet,Oriane Fiquet,Sylvie Darche,Sylvie Darche,Nicolas Serafini,Nicolas Serafini,Yan Li,Yan Li,Mathilde Dusséaux,Mathilde Dusséaux,Helene Strick-Marchand,Helene Strick-Marchand,James P. Di Santo,James P. Di Santo +18 more
TL;DR: This novel HIS mouse model should provide the opportunity to study the immunobiology of human NK cell and ILC subsets in vivo in response to various environmental challenges.
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