Yan Li
New York University
3 Papers
Yan Li is an academic researcher from New York University. The author has contributed to research in topics: Histone code & Histone methyltransferase. The author has an hindex of 3, co-authored 3 publications.
Chat about Author
Papers
The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate
Yan Li,Patrick Trojer,Chong-Feng Xu,Peggie Cheung,Alex J. Kuo,William J. Drury,Qi Qiao,Thomas A. Neubert,Rui-Ming Xu,Rui-Ming Xu,Or Gozani,Danny Reinberg +11 more
TL;DR: It is demonstrated that NSD2 can exhibit disparate target preferences based on the nature of the substrate provided, and proposed that DNA acts as an allosteric effector of N SD2 such that H3K36 becomes the preferred target.
297
The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation
TL;DR: This study reveals an autoregulatory mechanism of NSD1 and provides insight into the molecular mechanism of the nucleosomal substrate selectivity of this disease-related H3K36 methyltransferase.
L3MBTL2 Protein Acts in Concert with PcG Protein-Mediated Monoubiquitination of H2A to Establish a Repressive Chromatin Structure
Patrick Trojer,Alina R. Cao,Zhonghua Gao,Yan Li,Jin Zhang,Xiaoqin Xu,Guohong Li,Régine Losson,Hediye Erdjument-Bromage,Paul Tempst,Peggy J. Farnham,Danny Reinberg +11 more
TL;DR: These findings highlight a PcG/MBT collaboration that attains repressive chromatin without entailing histone lysine methylation marks.