5 Papers
94 Citations
Yan Li is an academic researcher from Dalian University of Technology. The author has contributed to research in topics: Systems pharmacology & Docking (molecular). The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Yan Li include Shihezi University.
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Papers
Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action of Huo-Xiang-Zheng-Qi Formula for the Treatment of Gastrointestinal Diseases.
Miaoqing Zhao,Yangyang Chen,Chao Wang,Wei Xiao,Shusheng Chen,Shuwei Zhang,Ling Yang,Yan Li,Yan Li +8 more
TL;DR: An insight of the therapeutic mechanism of TCMs on treating GI diseases from a multi-scale perspective is provided and may offer an efficient way for drug discovery and development from herbal medicine as complementary drugs.
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Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula
Yan Li,Jingxiao Zhang,Lilei Zhang,Xuetong Chen,Yanqiu Pan,Su-Shing Chen,Shuwei Zhang,Zhenzhong Wang,Wei Xiao,Ling Yang,Yonghua Wang +10 more
TL;DR: A novel systems pharmacology-based method which integrates pharmacokinetic filtering, target fishing and network analysis was developed and exemplified by a probe, i.e. Tianshu formula, a widely clinically used anti-migraine herbal formula in China which comprises of Rhizoma chuanxiong and Gastrodia elata.
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A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis
Yan Li,Jinghui Wang,Yuanchun Xiao,Yonghua Wang,Su-Shing Chen,Yinfeng Yang,Aiping Lu,Shuwei Zhang +7 more
TL;DR: The results show that the two herbs modulate the angiogenesis mediators through both direct and indirect pathways, and 21 common targets shared by Semen Strychni and TwHF bear major responsibility for treating RA.
42
Computational Analysis of Structure-Based Interactions for Novel H1-Antihistamines
TL;DR: The cross-validated result suggests that the developed models have excellent internal and external predictability and consistency, and would be of help for developing novel potent histamine H1 receptor antagonists, as well as exploring the H1-antihistamines interaction mechanism.
Systematic Investigation of Ginkgo Biloba Leaves for Treating Cardio-cerebrovascular Diseases in an Animal Model.
Yinfeng Yang,Yan Li,Jinghui Wang,Ke Sun,Weiyang Tao,Zhenzhong Wang,Wei Xiao,Yanqiu Pan,Shuwei Zhang,Yonghua Wang +9 more
TL;DR: The results show that GBLs exhibit a protective effect on CCVDs probably through regulating multiple pathways and hitting on multiple targets involved in several biological pathways, which will promote the development and application of TCM.