22 Papers
54 Citations
Yan Li is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 15, co-authored 21 publications. Previous affiliations of Yan Li include Zhejiang University & Chinese Academy of Sciences.
Chat about Author
Papers
Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production
Yan Li,Virginie Esain,Li Teng,Jian Xu,Wanda Kwan,Isaura M. Frost,Amanda D. Yzaguirre,Xiongwei Cai,Mauricio Cortes,Marijke W. Maijenburg,Joanna Tober,Elaine Dzierzak,Stuart H. Orkin,Kai Tan,Trista E. North,Nancy A. Speck +15 more
TL;DR: It is demonstrated that the primitive myeloid population contributes to the local inflammatory response to impact the scale of HSPC production in the AGM region, demonstrating that sterile inflammatory signaling is an evolutionarily conserved pathway regulating the production of H SPCs during embryonic development.
Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells
Michael J. Chen,Yan Li,Maria Elena De Obaldia,Qi Yang,Amanda D. Yzaguirre,Tomoko Yamada-Inagawa,Chris S. Vink,Avinash Bhandoola,Elaine Dzierzak,Nancy A. Speck +9 more
TL;DR: It is shown that the requirements for CBFβ in EMP and HSC formation in the conceptus are temporally and spatially distinct, with Ly6a expression specifically marking the HSC-generating hemogenic endothelium.
246
Metagenomic Analysis of Viruses from Bat Fecal Samples Reveals Many Novel Viruses in Insectivorous Bats in China
TL;DR: This study provides the first preliminary understanding of the virome of some bat populations in China, which may guide the discovery and isolation of novel viruses in the future.
229
Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans.
Junfa Yuan,Chung-Chau Hon,Yan Li,Dingming Wang,Ge-lin Xu,Huajun Zhang,Peng Zhou,Leo L.M. Poon,Tommy Tsan-Yuk Lam,Frederick C. Leung,Zhengli Shi +10 more
TL;DR: Findings reveal a closer evolutionary linkage between SCoV in humans and SLCoVs in R. sinicus, defining the scope of surveillance to search for the direct ancestor of human SCoVs.
114
NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets.
Bin Zhou,Yan Li,Yan Li,Jessica A. Belser,Melissa B. Pearce,Mirco Schmolke,Anju Subba,Zhengli Shi,Sherif R. Zaki,Dianna M. Blau,Adolfo García-Sastre,Terrence M. Tumpey,David E. Wentworth,David E. Wentworth +13 more
TL;DR: This study demonstrates that NSΔ5 is an ideal LAIV candidate, provides important information on the effects that different NS mutations have on the pandemic-H1N1 virus and shows that LAIVs can be engineered directly from the genomes of emerging/circulating influenza A viruses.
55