Yan Huang
Chinese Academy of Sciences
21 Papers
8 Citations
Yan Huang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Chemistry & Oxidative stress. The author has an hindex of 14, co-authored 21 publications. Previous affiliations of Yan Huang include Jiangsu University & Shandong Normal University.
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Papers
Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism.
TL;DR: The experimental results showed that the area under the concentration-time curve of candesartan was improved over 10-fold after CC was incorporated into CCN, which implicated that the nanoemulsion was very effective for enhancing the oral absorption of insoluble CC, and CCN showed the great potential for clinical application.
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Near-Infrared Fluorescence Probe for in Situ Detection of Superoxide Anion and Hydrogen Polysulfides in Mitochondrial Oxidative Stress
TL;DR: Two near-infrared fluorescent probes were successfully applied for visualizing exogenous and endogenous O2(•-) and H2Sn in living cells and in tumor mice models and demonstrate that H2 Sn can be promptly produced by mitochondrial oxidative stress, suggesting that H1N2 play critical roles in antioxidant systems.
182
Mitochondria-targeting near-infrared ratiometric fluorescent probe for selective imaging of cysteine in orthotopic lung cancer mice
Xiaoyu Zhang,Xiaoyu Zhang,Na He,Na He,Yan Huang,Fabiao Yu,Fabiao Yu,Bowei Li,Changjun Lv,Lingxin Chen,Lingxin Chen +10 more
TL;DR: Pressure Cy-OAcr is capable to detect and image Cys in three living cancer cell lines and their corresponding tumor-bearing mice models and can discriminate tumor lesions from normal tissues, indicating its significant potential applications for clinical auxiliary diagnosis of cancer.
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Sequential Detection of Superoxide Anion and Hydrogen Polysulfides under Hypoxic Stress via a Spectral-Response-Separated Fluorescent Probe Functioned with a Nitrobenzene Derivative
TL;DR: It is demonstrated that different hypoxic status lead to different concentrations between H2S n and O2•-.
50
Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models.
TL;DR: A fluorescent probe (Cy-GST) is reported for the detection of GSTs concentration fluctuations in cells and in mice models and demonstrated that the level of intracellular GSTs increase in the pulmonary fibrosis cells and mice models.
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