14 Papers
9 Citations
Yan Hao is an academic researcher from Stowers Institute for Medical Research. The author has contributed to research in topics: Chemistry & Lipid droplet. The author has an hindex of 6, co-authored 11 publications. Previous affiliations of Yan Hao include Hong Kong University of Science and Technology.
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Papers
Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain
Zhe Cao,Yan Hao,Chun Wing Fung,Yiu Yiu Lee,Pengfei Wang,Xuesong Li,Kang Xie,Wen Jiun Lam,Yifei Qiu,Ben Zhong Tang,Guanghou Shui,Pingsheng Liu,Jianan Y. Qu,Byung-Ho Kang,Ho Yi Mak +14 more
TL;DR: It is reported that a sub-population of lipid droplets (LDs), which are conserved organelles for fat storage, is defined by metabolite-modulated targeting of the C. elegans seipin ortholog, SEIP-1, to support the expansion of a subset of LDs.
Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.
Yan Hao,Ningyi Xu,Andrew C. Box,Laura Schaefer,Kasthuri Kannan,Ying Zhang,Laurence Florens,Christopher Seidel,Michael P. Washburn,Michael P. Washburn,Winfried Wiegraebe,Ho Yi Mak,Ho Yi Mak +12 more
TL;DR: The results indicate that, in addition to cytoplasmic functions, active EGL-4/PKG acts in the nucleus via a conserved Class I histone deacetylase complex to regulate gene expression pertinent to behavioral and physiological responses to cGMP.
Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network
Mark K. Adams,Charles A.S. Banks,Janet L. Thornton,Cassandra G. Kempf,Ying Zhang,Sayem Miah,Yan Hao,Mihaela E. Sardiu,Maxime Killer,Gaye Hattem,Alexis Murray,Maria L. Katt,Laurence Florens,Michael P. Washburn,Michael P. Washburn +14 more
TL;DR: It is shown that Sin3 paralog identity influences complex composition and chemical cross-linking MS identifies domains that mediate interactions between Sin3 proteins and binding partners, and the characterization of rare SIN3B proteoforms provides additional evidence for the existence of conserved and divergent elements within human Sin3protein.
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Integrative Modeling of a Sin3/HDAC Complex Sub-structure.
Charles A.S. Banks,Ying Zhang,Sayem Miah,Yan Hao,Mark K. Adams,Zhihui Wen,Janet L. Thornton,Laurence Florens,Michael P. Washburn,Michael P. Washburn +9 more
TL;DR: The architecture of this subassembly suggests that multiple factors have space to assemble to collectively influence the behavior of the catalytic subunit HDAC1.
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Integrated femtosecond stimulated Raman scattering and two-photon fluorescence imaging of subcellular lipid and vesicular structures
TL;DR: It is demonstrated that the multimodal NLO microscope system could sequentially image lipid structure/content and organelles, such as mitochondria, lysosomes, and the endoplasmic reticulum, which are intricately linked to lipid metabolism.
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