Yan Gao
Nanjing University
7 Papers
4 Citations
Yan Gao is an academic researcher from Nanjing University. The author has contributed to research in topics: Wnt signaling pathway & Xenopus. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Yan Gao include Stanford University.
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Papers
Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells.
Zan Zhang,Anhua Lei,Liyang Xu,Lu Chen,Yonglong Chen,Xuena Zhang,Yan Gao,Xiaoli Yang,Min Zhang,Ying Cao +9 more
TL;DR: It is shown that inhibition of the epigenetic modification enzyme enhancer of zeste homolog 2 (EZH2), histone deacetylases 1 and 3, lysine demethylase 1A (LSD1), or DNA methyltransferase 1 (DNMT1), which all promote cancer development and progression, leads to postmitotic neuron-like differentiation with loss of malignant features in distinct solid cancer cell lines.
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Kruppel-like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning
TL;DR: The results suggest that Klf factors are involved in the fine‐tuning of these genes during early embryogenesis, as well as in the regulation of key developmental signals.
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Temporal Vestibular Deficits in synaptojanin 1 ( synj1) Mutants
Yan Gao,Teresa Nicolson +1 more
TL;DR: In this paper, a method for assessing the vestibulospinal reflex (VSR) in larvae was developed to probe vestibular function with respect to postural control in zebrafish synj1 mutants, and the results suggest that defects in synaptic vesicle recycling give rise to fatigue of ribbons synapses and possibly other synapses of the VS circuit.
Deletion of RBP-Jkappa gene in mesenchymal cells causes rickets like symptoms in the mouse
TL;DR: In this paper , the authors further extended this regulation axis to the other two kind of skeletal cells: chondrocytes and osteoblasts, and found that mice with conditional mesenchymal deletion of RBP-Jkappa developed Rickets like symptoms.
Klf4 is required for germ-layer differentiation and body axis patterning during Xenopus embryogenesis
TL;DR: It is concluded that Klf4 is required for germ-layer differentiation and body axis patterning by means of rendering early embryonic cells competent to differentiation signals.