Yan Cui
Leibniz Association
4 Papers
29 Citations
Yan Cui is an academic researcher from Leibniz Association. The author has contributed to research in topics: Ezrin & Gene. The author has an hindex of 4, co-authored 4 publications.
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Papers
Feedback activation of neurofibromin terminates growth factor-induced Ras activation
Anne Hennig,Robby Markwart,Katharina Wolff,Katja Schubert,Yan Cui,Ian A. Prior,Manuel A Esparza-Franco,Graham Ladds,Ignacio Rubio +8 more
TL;DR: These findings ascribe a precise role to neurofibromin in growth factor-dependent control of Ras activity and illustrate how, by engaging Ras-GAP activity, mitogen-challenged cells play safe to ensure a timely termination of the Ras signal irrespectively of the reigning rate of nucleotide exchange.
Regulation of Son of sevenless by the membrane-actin linker protein ezrin.
Katja J. Geißler,M. Juliane Jung,Lars Björn Riecken,Tobias Sperka,Yan Cui,Stephan Schacke,Ulrike Merkel,Robby Markwart,Ignacio Rubio,Manuel E. Than,Constanze Breithaupt,Sebastian Peuker,Reinhard Seifert,Ulrich Benjamin Kaupp,Peter Herrlich,Helen Morrison +15 more
TL;DR: The mechanism by which ezrin modulates SOS activity and thereby Ras activation is reported, which is relevant for human cancer as well as all physiological processes involving Ras.
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Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability
Lars Björn Riecken,Hasan Tawamie,Carsten Dornblut,Rebecca Buchert,Amina Ismayel,Alexander Schulz,Johannes Schumacher,Heinrich Sticht,Katja J. Pohl,Yan Cui,André Reis,Helen Morrison,Rami Abou Jamra +12 more
TL;DR: Functional analysis revealed that the altered ezrin protein is no longer able to bind Ras and facilitate its activation, thus revealing a possible mechanism for its phenotype in humans.
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Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells
Astrid Petermann,Yvonn Stampnik,Yan Cui,Helen Morrison,Doreen Pachow,Nadine Kliese,Christian Mawrin,Frank-D. Böhmer +7 more
TL;DR: Induction of MMP-9 expression promoted by DEP-1 deficiency, or potentially by growth factors and inflammatory cytokines, as a mechanism contributing to meningioma brain invasiveness is suggested.
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