Yan Chen
Shanghai Jiao Tong University
4 Papers
Yan Chen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Chemistry & Gene. The author has co-authored 1 publications.
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Papers
Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression
Xiao Yang,Yan Chen,Jiadong Guo,Jiaxin Li,Pu Zhang,Huanming Yang,Kewei Rong,Tangjun Zhou,Jingke Fu,Jie‐Zu Zhao +9 more
TL;DR: In this article , polydopamine nanoparticles (PDA NPs) were shown to inhibit oxidative stress-induced ferroptosis in nucleus pulposus (NP) cells in vitro.
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Polydopamine-coated UiO-66 nanoparticles loaded with perfluorotributylamine/tirapazamine for hypoxia-activated osteosarcoma therapy
Hong-Fang Chen,You Fu,Kai Feng,Yifan Zhou,Xin Wang,Haohan Huang,Yan Chen,Wenhao Wang,Yuanjing Xu,Haijun Tian,Yuanqing Mao,Jinwu Wang,Zhiyuan Zhang +12 more
TL;DR: In this paper, a nanomedicine based on oxygen absorbing perfluorotributylamine (PFA) and the bioreductive prodrug tirapazamine (TPZ) was prepared by using a polydopamine (PDA)-coated UiO-66 metal organic framework (MOF) as the drug carrier.
Verapamil attenuates intervertebral disc degeneration by suppressing ROS overproduction and pyroptosis via targeting the Nrf2/TXNIP/NLRP3 axis in four-week puncture-induced rat models both in vivo and in vitro.
Yan Chen,Xiankun Cao,Bin Pan,Han Du,Baixing Li,Xiao Yang,Xuzhuo Chen,Xin Wang,Tangjun Zhou,An Qin,Changqing Zhao,Jie‐Zu Zhao +11 more
TL;DR: administration of verapamil mitigated the TBHP-induced overproduction of reactive oxygen species and activation of the NLRP3 inflammasome, thus protecting cells from pyroptosis, apoptosis, and extracellular matrix degradation and indicate the potential therapeutic effects and mechanisms of action of verAPamil in the treatment of IVDD.
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Identification and Validation of Genes Related to RNA Methylation Modification in Diabetic Retinopathy.
Xue Wang,Xiaomei Li,Yuan Zong,Jian Yu,Yan Chen,Minghui Zhao,Danping Wu,Yujie Liao,Chunhui Jiang,Haohao Zhu +9 more
TL;DR: Differentially expressed genes were mainly enriched in the RNA-methylation-medication pathways and biological function, and the results of immune infiltration analysis proved that eosinophils aggregated more in diabetic group, while T cells follicular helper aggregates more in normal samples.