Yan Chen
4 Papers
Yan Chen is an academic researcher. The author has contributed to research in topics: Genome-wide association study & Micelle. The author has an hindex of 1, co-authored 1 publications.
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Papers
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
Zhanju Liu,Ruize Liu,Han Gao,Xiang Gao,Ruicong Sun,Xiaoming Liu,Yong-joong Kim,Ho Su Lee,Yosuke Kawai,Masao Nagasaki,Junji Umeno,Katsushi Tokunaga,Yoshitaka Kinouchi,Atsushi Masamune,Wenzhao Shi,Zhenglin Guo,K. Yuan,Maria del Rosario Abreu,Jean-Paul Achkar,Vibeke Andersen,Charles Bernstein,Steven R. Brant,Luis Bujanda,Siew C. Ng,Lee A. Denson,Richard H. Duerr,Lynnette R. Ferguson,Denis Franchimont,Andre Franke,Richard B. Gearry,Hakon Hakonarson,Jonas Halfvarson,Caren Heller,Antonio Julià,Judith R. Kelsen,Hamed Khalili,Subra Kugathasan,Juozas Kupcinskas,Anna Latiano,Edouard Louis,Reza Malekzadeh,Jacob L. McCauley,David T. Okou,Timothy R. Orchard,Aarno Palotie,Miles Parkes,Joel Pekow,Uroš Potočnik,Graham L. Radford-Smith,John D. Rioux,Gerhard Rogler,Bruce E. Sands,Mark S. Silverberg,H. Sokol,Severine Vermeire,Rinse K. Weersma,Ramnik J. Xavier,Nai-Zhong Hu,Qian Cao,Yufang Wang,Yinglei Miao,Hongjie Zhang,Xiao-Ping Lv,Xiang Gao,Hui Zhang,Jingling Su,Baisui Feng,Ye Zhao,Liangru Zhu,Yan Chen,Lan Zhu,Chunxiao Chen,Yali Wang,Ying-De Wang,Zhi Pang,Yi Chen,Xiaolan Zhang,Hui Li,Qin Yu,Mei Ye,Sumin Zhang,Wen Tang,Mei Wang,Xiaocang Cao,Ruixin Zhu,Guangxi Zhou,Zhaolian Bian,Xiaofeng Guo,Xiaoli Wu,Jinchun Liu,Wei Xu,Yuqin Li,Qin Guo,Zhiguo Guo,Shu-Xia Zhu,Dalin Li,Jianjun Liu,Tian Ge,Judy H. Cho,Mark J. Daly,Dermot P.B. McGovern,Byong Duk Ye,Kyuyoung Song,Yoichi Kakuta,Mingsong Li,Hailiang Huang +105 more
TL;DR: The largest IBD study of individuals of East Asian (EAS) ancestries is reported, finding 80 IBD loci in EAS alone and 320 when meta-analyzed with ~370,000 EUR individuals, among which 81 are new.
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The Study of Tacrolimus-Loaded Polyion Complex Micelles for Oral Delivery.
TL;DR: Tests of cell uptake and the immunosuppressive effect of FK506-loaded F127-CS/NaDC micelles in a rat liver transplantation model was better than that of Fk506 solution, which indicated enhanced oral absorption ofFK506 in FK505- loaded F 127- CS/Na DC micells.
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Construction of albumin based nanoparticles utilizing paclitaxel-fatty acid prodrug that mimicking the natural fatty-acid binding process in vivo to synergistically elevate ROS withβ-lapachone for cooperative cancer therapy.
Yanli Zhao,Yimu Li,Yan Chen,Yuanyuan Li,Lingbing Li,Wei Xu +5 more
TL;DR: Researchers developed albumin-based nanoparticles co-loaded with paclitaxel and β-lapachone, mimicking natural fatty-acid binding, to synergistically elevate ROS and enhance apoptosis in cancer cells, demonstrating improved tumor targeting and growth inhibition.