Yan Chen
Temple University
8 Papers
21 Citations
Yan Chen is an academic researcher from Temple University. The author has contributed to research in topics: Microvesicles & Reperfusion injury. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of Yan Chen include Tianjin Medical University.
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Papers
Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke.
TL;DR: Results indicate that proteolytically active MVs induced by tobacco smoke may be novel mediators of clinical important matrix destruction in smokers.
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Microvesicles derived from hypoxia/reoxygenation-treated human umbilical vein endothelial cells promote apoptosis and oxidative stress in H9c2 cardiomyocytes.
Qi Zhang,Man Shang,Meng-Xiao Zhang,Yao Wang,Yan Chen,Yan-Na Wu,Ming-Lin Liu,Ming-Lin Liu,Jun-Qiu Song,Yan-Xia Liu +9 more
TL;DR: It is shown that EMVs released during H/R injury are pro-apoptotic, pro-oxidative and directly pathogenic to cardiomyocytes in vitro, and they may impair myocardium by promoting apoptosis and oxidative stress.
Decreased secretion of adiponectin through its intracellular accumulation in adipose tissue during tobacco smoke exposure
Mingzhen Li,Chunjun Li,Yu Liu,Yan Chen,Xiangdong Wu,Demin Yu,Victoria P. Werth,Victoria P. Werth,Kevin Jon Williams,Kevin Jon Williams,Ming-Lin Liu,Ming-Lin Liu,Ming-Lin Liu +12 more
TL;DR: Tobacco smoke exposure traps HMW ADPN intracellularly, thereby blocking its secretion, and may help to explain the increased risk of T2DM in smokers.
•Journal Article
[Study on ultrastructure of cardioprotection of ramipril against ischemia/reperfusion injury in diabetic rats].
Yan-Na Wu,Yan Chen,Zhe Zhang,Ya-Li Dong,Xue-Kuan Yu,Jian-Jie Jiao,Yi Kang,Wei-Zhen Gao,Jian-Shi Lou,Yan-Xia Liu +9 more
TL;DR: Ramipril administered for 4 weeks induces myocardial protection in diabetic rats, which is similar to that of IPC, and the mechanism may be involved in protection of cardiocytes and mitochondria, and improvement of endothelial function.
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•Journal Article
Abstract 162: Exposure of Human Macrophages to Tobacco Smoke Induces Hmgb1 Release on Microvesicles That Cause Monocyte Recruitment and Impairment of Insulin Signaling in Adipocytes
TL;DR: Exposure of human macrophages to smoke upregulates HMGB1 expression and causes its release on microvesicles, which mediate harmful crosstalk from macrophage-adipocytes to adipocytes, and impairments in insulin signaling that may contribute to insulin resistance and the development of T2DM in tobacco smoke exposure are indicated.
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