7 Papers
9 Citations
Yan Chen is an academic researcher from McGovern Institute for Brain Research. The author has contributed to research in topics: Semantic dementia & Semantic memory. The author has an hindex of 4, co-authored 7 publications. Previous affiliations of Yan Chen include Zhejiang University.
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Papers
A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia
Junhua Ding,Junhua Ding,Keliang Chen,Haoming Liu,Lin Huang,Yan Chen,Yan Chen,Yingru Lv,Qing Yang,Qihao Guo,Zaizhu Han,Matthew A. Lambon Ralph +11 more
TL;DR: It is shown that the degree of generalised semantic impairment is related to the patients’ total, bilateral ATL atrophy, and the data-driven model repositions semantics, language, social behaviour and face recognition into a continuous frontotemporal neurocognitive space.
White matter basis for the hub-and-spoke semantic representation: evidence from semantic dementia.
Yan Chen,Yan Chen,Lin Huang,Keliang Chen,Junhua Ding,Yumei Zhang,Qing Yang,Yingru Lv,Zaizhu Han,Qihao Guo +9 more
TL;DR: The ‘hub-and-spoke’ theory of semantic representation proposes that semantic knowledge is processed in a network comprising modality-specific regions connected to an amodal semantic hub, which is identified by studying semantic dementia.
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White matter networks dissociate semantic control from semantic knowledge representations: Evidence from voxel-based lesion-symptom mapping.
Junhua Ding,Junhua Ding,Keliang Chen,Nan Zhang,Nan Zhang,Mingyue Luo,Xiaoxia Du,Yan Chen,Yan Chen,Qing Yang,Yingru Lv,Yumei Zhang,Luping Song,Zaizhu Han,Qihao Guo +14 more
TL;DR: Brain-damaged patients with semantic dementia and semantic aphasia, who had selective predominant deficits in semantic knowledge and semantic control, were recruited and regression models were built to identify the white matter network associated with the semantic performance of each patient group.
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Topological Alterations and Symptom-Relevant Modules in the Whole-Brain Structural Network in Semantic Dementia.
Junhua Ding,Keliang Chen,Weibin Zhang,Ming Li,Yan Chen,Qing Yang,Yingru Lv,Qihao Guo,Zaizhu Han +8 more
TL;DR: The skeleton of the neuroanatomical network of SD patients is illustrated and the key role of the left temporal/occipital/parietal module and the left frontal module in semantic processing is highlighted.
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Neural substrates of amodal and modality-specific semantic processing within the temporal lobe: A lesion-behavior mapping study of semantic dementia
TL;DR: The found that the left anterior fusiform gyrus was an amodal semantic hub whose gray matter volume correlated significantly with both modalities, and the structure of semantic network in the temporal lobe was refined, deepening the understanding of the critical role of the temporal lobes in semantic processing.