Yan Chen
Zunyi Medical College
13 Papers
15 Citations
Yan Chen is an academic researcher from Zunyi Medical College. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 8 publications.
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Papers
Pilot study of expanded carrier screening for 11 recessive diseases in China: results from 10,476 ethnically diverse couples
Sumin Zhao,Jiale Xiang,Chunna Fan,Asan,Xuan Shang,Xinhua Zhang,Yan Chen,Baosheng Zhu,Wangwei Cai,Shaoke Chen,Ren Cai,Xiaoling Guo,Chonglin Zhang,Yuqiu Zhou,Shuodan Huang,Yanhui Liu,Biyan Chen,Shanhuo Yan,Yajun Chen,Hongmei Ding,Fengyu Guo,Yaoshen Wang,Wenwei Zhong,Yaping Zhu,Wang Yaling,Chao Chen,Yun Li,Hui Huang,Mao Mao,Ye Yin,Jian Wang,Huanming Yang,Xiangmin Xu,Jun Sun,Zhiyu Peng +34 more
TL;DR: The data demonstrate the feasibility of ECS, and provide evidence that ECS is a promising alternative to traditional one-condition screening strategies, and the lessons learned from this experience should be applicable for other countries or regions with diverse ethnic groups.
Early genetic screening uncovered a high prevalence of thalassemia among 18 309 neonates in Guizhou, China.
Mei Tan,Yue Bai,Xiang-Mei Zhang,Jian Sun,Cheng-Shuang Huang,Run-Mei Tian,Yuhang Yang,Xi Luo,Qiong Su,Liu-Song Wu,Libo Zheng,Jing Xia,Hongmei Murong,Ping Zhu,Fan Yang,Xiaosong Zhong,Jindong Chen,Yan Chen +17 more
TL;DR: Wang et al. as mentioned in this paper used NGS-Gap-PCR to detect thalassemia-rich genotypes in infants in Guizhou Province, China, where the carrier rates for α-thalassemia were 8.91% and 3.36%, respectively.
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LOVD-DASH: A comprehensive LOVD database coupled with diagnosis and an at-risk assessment system for hemoglobinopathies.
Li Zhang,Qianqian Zhang,Yaohua Tang,Peikuan Cong,Yuhua Ye,Chen Shiping,Xinhua Zhang,Yan Chen,Baosheng Zhu,Wangwei Cai,Shaoke Chen,Ren Cai,Xiaoling Guo,Chonglin Zhang,Yuqiu Zhou,Jie Zou,Yan-Hui Liu,Biyan Chen,Shanhuo Yan,Yajun Chen,Yuehong Zhou,Hongmei Ding,Xiarong Li,Dianyu Chen,Jianmei Zhong,Xuan Shang,Xuanzhu Liu,Ming Qi,Xiangmin Xu +28 more
TL;DR: A variant database which couples an online auxiliary diagnosis and at‐risk assessment system for hemoglobinopathies (DASH), integrated into the Leiden Open Variation Database (LOVD), in which all reported variants focusing on a Chinese population are included.
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Severe Thalassemia Caused by Hb Zunyi [β147(HC3)Stop→Gln; HBB: c.442T>C)] on the β-Globin Gene.
Qiong Su,Shiping Chen,Liu-Song Wu,Run-Mei Tian,Xiaoqin Yang,Xiaoyan Huang,Yan Chen,Zhiyu Peng,Jindong Chen +8 more
TL;DR: The identification of the novel β variant, Hb Zunyi, has been added to the human globin database and will shed light on future diagnosis of hemoglobinopathy/thalassemia and genetic counseling.
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Progranulin regulates the development and function of NKT2 cells through EZH2 and PLZF
Zuochen Du,Lu Huang,Xin Dai,Di Yang,Linlin Niu,Heather Miller,Changshun Ruan,Han Li,Leling Hu,L. Zhou,Ding Jian,Jian Sun,Xiaoqi Shi,Pei-Hsing Huang,Yan Chen,Xiao-Yan Zhao,Chaohong Liu +16 more
TL;DR: A new pathway is revealed (PGRN-EZH2-PLZF), which regulates the Th2 responses of iNKT cells and provides a potentially new target for asthma treatment.
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