16 Papers
282 Citations
Yan Bai is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Muscle contraction & Ryanodine receptor. The author has an hindex of 16, co-authored 16 publications.
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Papers
Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptor.
Yan Bai,Michael J. Sanderson +1 more
TL;DR: The results indicate that the relaxant effect of cAMP-elevating agents on airway SMCs is achieved by decreasing the Ca2- oscillation frequency by reducing internal Ca2+ release through IP3 receptors.
A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations
James Sneyd,Krasimira Tsaneva-Atanasova,V. Reznikov,Yan Bai,Michael J. Sanderson,David I. Yule +5 more
TL;DR: It is shown that muscarinic receptor-mediated, long- period Ca2+ oscillations in pancreatic acinar cells depend on [IP3] oscillations, whereas short-period Ca2+, airway smooth muscle do not.
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Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slices
Yan Bai,Michael J. Sanderson +1 more
TL;DR: Ryanodine-caffeine treatment is a valuable tool for investigating the contractile mechanisms of SMCs while avoiding nonspecific effects due to cell permeabilization and cAMP-elevating agents contribute to the relaxation of airway SMCs through Ca(2+) desensitization.
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A Mathematical Model of Airway and Pulmonary Arteriole Smooth Muscle
TL;DR: It is predicted that oscillations in calcium concentration, commonly observed during agonist-induced smooth muscle contraction, cause a significantly greater contraction than an elevated steady calcium concentration and that murine airway SMCs exploit a Ca2+-dependent mechanism to favor a default state of relaxation.
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The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca2+ signaling of airway smooth muscle cells
TL;DR: Results indicate that agonist-induced Ca( 2+) oscillations in mouse small airway SMCs are primary mediated via IP(3)Rs and that tetracaine induces relaxation by both decreasing Ca(2+) sensitivity and inhibiting agonists' Ca(1+)-permeable SMCs via an IP( 3)-dependent mechanism.
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