Yaki Eidelstein
Weizmann Institute of Science
18 Papers
82 Citations
Yaki Eidelstein is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Cytotoxic T cell & Transplantation. The author has an hindex of 7, co-authored 18 publications.
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Papers
CTLs respond with activation and granule secretion when serving as targets for T-cell recognition.
Oren Milstein,David Hagin,Assaf Lask,Shlomit Reich-Zeliger,Elias Shezen,Eran Ophir,Yaki Eidelstein,Ran Afik,Yaron E. Antebi,Michael L. Dustin,Yair Reisner +10 more
TL;DR: It is demonstrated that CTLs actively respond to recognition by polarizing their cytotoxic granules to the contact area, releasing their lethal cargo, and vigorously proliferating, and these data suggest a novel mechanism in which the entire cascade generally triggered by TCR engagement is "hijacked" in C TLs serving as targets for T cell recognition without TCR ligation.
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Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7.
Lior Zangi,Yael Zlotnikov Klionsky,Liran Yarimi,Esther Bachar-Lustig,Yaki Eidelstein,Elias Shezen,David Hagin,Yumi Ito,Toshiyuki Takai,Shlomit Reich-Zeliger,Assaf Lask,Oren Milstein,Steffen Jung,Vera Shinder,Yair Reisner +14 more
TL;DR: The generation of a highly defined population of imDCs from hematopoietic progenitors and the direct visualization of the fate of TCR-transgenic alloreactive CD4(+) and CD8(+) T cells after encountering cognate or noncognate im DCs are described.
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Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells.
TL;DR: In conclusion, anti-third-party Tcms, which home to recipient LNs and effectively delete antidonor T cells, could provide an effective and novel tool for overcoming rejection of BM allografts.
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Murine anti–third-party central-memory CD8+ T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells
Eran Ophir,Noga Or-Geva,Irina Gurevich,Orna Tal,Yaki Eidelstein,Elias Shezen,Raanan Margalit,Assaf Lask,Guy Shakhar,David Hagin,Esther Bachar-Lustig,Shlomit Reich-Zeliger,Andreas Beilhack,Robert S. Negrin,Yair Reisner +14 more
TL;DR: Anti-third-party Tcms support TDBMT engraftment under reduced-conditioning through lymph-node sequestration and deletion of HADTCs, offering a novel and potentially safe approach for attaining stable hematopoietic chimerism.
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Patent
Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
Yair Reisner,Yaki Eidelstein,Eran Ophir,Assaf Lask,Ran Afik,Noga Or-Geva,Esther Bachar-Lustig +6 more
- 06 Sep 2012
TL;DR: In this paper, a method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed.
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