Yael S. Grossman
Icahn School of Medicine at Mount Sinai
11 Papers
25 Citations
Yael S. Grossman is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Dendritic spine & Speech perception. The author has an hindex of 10, co-authored 11 publications. Previous affiliations of Yael S. Grossman include Allen Institute for Brain Science.
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Papers
A Map for Social Navigation in the Human Brain.
Rita M. Tavares,Avi Mendelsohn,Yael S. Grossman,Christian Hamilton Williams,Matthew L. Shapiro,Yaacov Trope,Daniela Schiller +6 more
TL;DR: The results suggest that the hippocampus is crucial for social cognition, and imply that beyond framing physical locations, the hippocampus computes a more general, inclusive, abstract, and multidimensional cognitive map consistent with its role in episodic memory.
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Establishment of a repeated social defeat stress model in female mice
Aki Takahashi,Aki Takahashi,Aki Takahashi,Jia Ru Chung,Song Zhang,Hongxing Zhang,Yael S. Grossman,Hossein Aleyasin,Meghan E. Flanigan,Madeline L. Pfau,Caroline Menard,Dani Dumitriu,Georgia E. Hodes,Bruce S. McEwen,Eric J. Nestler,Ming-Hu Han,Scott J. Russo +16 more
TL;DR: A female mouse model of RSDS is established by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the Ventromedial hypothalamus (VMHvl) to demonstrate that females susceptible to RSDS display social avoidance, anxiety-like behavior, reduction of body weight, and elevated levels of circulating interleukin 6.
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Glutamatergic regulation prevents hippocampal-dependent age-related cognitive decline through dendritic spine clustering
Ana C. Pereira,Hilary K. Lambert,Yael S. Grossman,Dani Dumitriu,Dani Dumitriu,Rachel Waldman,Sophia K. Jannetty,Katina C. Calakos,William G. M. Janssen,Bruce S. McEwen,John H. Morrison,John H. Morrison +11 more
TL;DR: It is shown that riluzole can protect against some of the synaptic alterations in hippocampus that are linked to age-related memory loss in rats and induces clustering of dendritic spines, which further elucidate neuroplastic changes in glutamatergic circuits with aging and advance therapeutic development to prevent and treat age- related cognitive decline.
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Selective Loss of Thin Spines in Area 7a of the Primate Intraparietal Sulcus Predicts Age-Related Working Memory Impairment
Sarah E. Motley,Yael S. Grossman,William G.M. Janssen,Mark G. Baxter,Peter R. Rapp,Dani Dumitriu,John H. Morrison,John H. Morrison,John H. Morrison +8 more
TL;DR: These data show that age-related working memory changes are not limited to disruptions of the prefrontal cortex but also include an association region heavily interconnected with prefrontal cortex, and support the hypothesis that cognitive aging is driven primarily by synaptic changes, and more specifically by changes in thin spines, in key association areas.
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Estimating speech spectra for copy synthesis by linear prediction and by hand.
Robert E. Remez,Kathryn R. Dubowski,Morgana L. Davids,Emily F. Thomas,Nina U. Paddu,Yael S. Grossman,Marina Moskalenko +6 more
TL;DR: Intelligibility tests revealed uniformly good performance with sentences created by hand-estimation and a minimal decrease in intelligibility with estimation by linear prediction due to manner variation with continuous voicing.