35 Papers
176 Citations
Ya Ni is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Capacitation & Sperm. The author has an hindex of 12, co-authored 30 publications. Previous affiliations of Ya Ni include Zhejiang University & Academy of Medical Sciences, United Kingdom.
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Papers
CFTR mutations in men with congenital bilateral absence of the vas deferens (CBAVD): a systemic review and meta-analysis
TL;DR: A systemic review and meta-analysis shows a high frequency of CFTR mutations in CBAVD patients, and these exhibit evident ethnic differences, including an increased frequency of cases with two mutations in Caucasian patients than in Non-Caucasian.
Cl− Is Required for HCO3− Entry Necessary for Sperm Capacitation in Guinea Pig: Involvement of a Cl−/HCO3− Exchanger (SLC26A3) and CFTR
Wen Ying Chen,Wen Ying Chen,Wen Ming Xu,Zhang Hui Chen,Ya Ni,Yu Ying Yuan,Sichang Zhou,Wen Wei Zhou,Lai Ling Tsang,Yiu Wa Chung,Pia Höglund,Hsiao Chang Chan,Qi Xian Shi +12 more
TL;DR: Capacitation-associated HCO3−-dependent events, including increased intracellular pH, cAMP production, and protein tyrosine phosphorylation, also depend on Cl− concentrations, which indicates that Cl− is required for the entry of H CO3− that is necessary for sperm capacitation.
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Critical role of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm.
Hsiao Chang Chan,Qi Xian Shi,Chen Xi Zhou,Xiao Fei Wang,Wen Ming Xu,Wen Ying Chen,Wen Ying Chen,Ai Jun Chen,Ya Ni,Yu Ying Yuan +9 more
TL;DR: Results are consistent with a critical role of CFTR in controlling uterine HCO3- secretion and sperm fertilizing capacity, suggesting that CFTR may be a potential target for post-meiotic regulation of fertility.
76
Association of the CAG repeat polymorphisms in androgen receptor gene with polycystic ovary syndrome: a systemic review and meta-analysis.
TL;DR: This meta-analysis demonstrates no evident association between the CAG length variations in AR gene and PCOS risk, while the C AG length appears to be positively associated with T levels in PCOS patients.
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Hsp90 modulates human sperm capacitation via the Erk1/2 and p38 MAPK signaling pathways.
TL;DR: In this article, the authors explored whether heat shock protein 90 (Hsp90) modulates human sperm capacitation via the Erk1/2 and p38 MAPK signaling pathways and found that 17-allylamino-17-demethoxygeldanamycin (17-AAG) reduced the interaction between Hsp90 and Cdc37.