Ya-Hui Chi
National Health Research Institutes
58 Papers
397 Citations
Ya-Hui Chi is an academic researcher from National Health Research Institutes. The author has contributed to research in topics: Biology & Lamin. The author has an hindex of 22, co-authored 53 publications. Previous affiliations of Ya-Hui Chi include China Medical University (PRC) & China Medical University (Taiwan).
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Papers
Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies
Chia-Yen Chen,Ya-Hui Chi,Rafidah Mutalif,Matthew F. Starost,Timothy G. Myers,Stasia A. Anderson,Colin L. Stewart,Kuan-Teh Jeang +7 more
TL;DR: Reduction of SUN1 overaccumulation in LMNA mutant fibroblasts and in cells derived from HGPS patients corrected nuclear defects and cellular senescence implicate Sun1 protein accumulation as a common pathogenic event in Lmna(-/-), LmNAΔ9, and HGPS disorders.
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Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes.
TL;DR: It is demonstrated that chromosome de-condensation needs the function of an inner nuclear membrane (INM) protein hsSUN1 and a membrane-associated histone acetyltransferase (HAT), hALP to acetylate histones for de-compacting DNA at the end of mitosis.
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The nuclear envelopathies and human diseases
TL;DR: The functions of the nuclear envelope are reviewed in chromosome organization, gene expression, DNA repair and cell cycle progression, and correlate deficiencies in envelope function with human pathologies.
Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies
Zi-Jie Chen,Wan-Ping Wang,Yu-Ching Chen,Jing-Ya Wang,Wen-Hsin Lin,Lin-Ai Tai,Gan-Guang Liou,Chung-Shi Yang,Ya-Hui Chi,Ya-Hui Chi +9 more
TL;DR: It is demonstrated that SUN1 contributes to progerin-elicited structural changes in the nuclear envelope and the endoplasmic reticulum (ER) network, and the dysregulated interaction of SUN1 and proger in the ER during nuclear envelope reformation determines the progression of HGPS.
65
Aneuploidy and cancer.
Ya-Hui Chi,Kuan-Teh Jeang +1 more
TL;DR: The cell's euploid status is influenced by, amongst other mechanisms, an intact spindle assembly checkpoint (SAC), an accurate centrosome cycle, and proper cytokinesis, which contribute to cellular aneuploidy.
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