7 Papers
Ya Gao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Haematopoiesis & Zebrafish. The author has an hindex of 7, co-authored 7 publications.
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Papers
Fev regulates hematopoietic stem cell development via ERK signaling.
Lu Wang,Tianhui Liu,Linjie Xu,Ya Gao,Yonglong Wei,Cai-Wen Duan,Guo-Qiang Chen,Shuo Lin,Roger Patient,Bo Zhang,Dengli Hong,Feng Liu +11 more
TL;DR: Genetic and chemical analyses support a mechanism whereby Fev regulates HSC through direct regulation of ERK signaling, and indicate that Fev-ERK signaling is essential for hemogenic endothelium-based HSC development.
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Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish
TL;DR: It is shown that in zebrafish, ncor2 is required for hematopoietic stem cell (HSC) development by repressing fos-vegfd signaling by identifying a novel regulatory mechanism for Ncor2 through Fos-Vegfd-Notch signaling cascade during HSC development inZebrafish embryos.
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Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish
TL;DR: It is shown that Foxn1 functions in thymus development through Mcm2 in the zebrafish, and the results reveal that the foxn1-mcm2 axis plays a central role in the genetic regulatory network controlling thymUS development in zebra fish.
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5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.
TL;DR: 5-hydroxytryptamine can enhance the generation of hematopoietic stem and progenitor cells (HSPCs) in vitro and is essential for the survival of HSPCs in vivo during embryogenesis, and 5-HT signaling may be a potential therapeutic target for promoting HSPC survival.
Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence.
TL;DR: It is shown that interplay of Smad1/5 and ERK signalling is essential for haemogenic endothelium-based HSC emergence and new insights are provided into the in vitro generation of transplantable HSCs for potential clinical applications.