http://neist.csircentral.net/350/1/970_TL_2002_43p895.pdf

Studies on uracils: a facile one-pot synthesis of pyrazolo[3,4-d]pyrimidines

Aromatic nucleophilic denitrocyclization reactions

Several 7-methyl-5-alkyl-2-vinylpyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-diones were prepared. The successful cyclization and alkylation of 6-(α-methylbenzylidenehydrazino)-1-methyluracils2a–d using dimethylformamide acetals at high temperature provided6a–d,7a–d, and8a–d. Treatment of6a–d and7a–d with acid afforded 7-methyl-5-alkylpyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-diones9a,b; under the same conditions,3a–d reacted to 7-methylpyrazolo[3,4-d]-pyrimidine-4,6(5H)-dione (4) in good yield.

DMF acetals as alkylating and cyclizing agents: A facile route to substituted pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-diones

N‐bromosuccinimide in heterocyclic synthesis. Synthesis of pyrazolo[3,4‐d]pyrimidines, Pyrimido[5,4‐e]‐as‐triazines, and pyrimido[4,5‐c]pyridazines from 6‐arylidenehydrazino‐1,3‐dimethyluracil derivatives

Treatment of 1,3-dimethyl-6-hydrazinouracil with the appropriate dimethylformamide dialkylacetal afforded the, corresponding 2-alkyl-5,7-dimethylpyrazolo[3,4-d]pyrimidine-4,6-(5H,7H)diones. The reaction of 1,3-dimethyl-6-(α-methylbenzylidenehydrazino)uracils with dimethylformamide dimethylacetal or triethyl orthoformate gave the corresponding 5,7-dimethyl-2-vinylpyrazolo[3,4-d]pyrimidine-4,6(5H,7H)diones, respectively. Similarly, treatment of 1,3-dimethyl-6-(α-methylbenzylidenehydrazino)uraeils with triethyl orthopropionate yielded the corresponding 5,7-dimethyl-3-ethyl-2-vinylpyrazolo[3,4-d]pyrimidine-4,6(5H,7H)diones.

A New, Convenient Synthesis of 2-Alkyl- and 2-Vinylpyrazolo [3,4-d]pyrimidine Derivatives

Treatment of 6-chloro-3,4-dimethyl-5-nitrouracil with a wide variety of ketone and aldehyde hydrazones provides a novel one-step synthesis of pyrazolo[3,4-d]pyrimidines.

A new synthesis of pyrazolo[3,4-d]pyrimidines

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A new synthesis of pyrazolo[3,4-d]pyrimidines