Y.M. Dennis Lo
The Chinese University of Hong Kong
314 Papers
4.5K Citations
Y.M. Dennis Lo is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Biology & Prenatal diagnosis. The author has an hindex of 91, co-authored 297 publications.
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Papers
Presence of fetal DNA in maternal plasma and serum
Y.M. Dennis Lo,Noemi Corbetta,Paul Chamberlain,Vik Rai,Ian L. Sargent,Christopher W.G. Redman,James S. Wainscoat +6 more
TL;DR: The finding of circulating fetal DNA in maternal plasma may have implications for non-invasive prenatal diagnosis, and for improving the understanding of the fetomaternal relationship.
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Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis
Y.M. Dennis Lo,Mark S.C. Tein,Tze K. Lau,Christopher J. Haines,Tse N. Leung,Priscilla M.K. Poon,James S. Wainscoat,Philip J. Johnson,Allan M. Z. Chang,N. Magnus Hjelm +9 more
TL;DR: In this paper, a real-time quantitative PCR assay was developed to measure the concentration of fetal DNA in maternal plasma and serum, and the results showed that fetal DNA is present in high concentrations in maternal placenta, reaching a mean of 25.4 genome equivalents/ml (range 3.3-69.4) in early pregnancy and 292.2 genome equivalents /ml(range 76.9-769) in late pregnancy.
Rapid Clearance of Fetal DNA from Maternal Plasma
TL;DR: The rapid turnover of circulating DNA suggests that plasma DNA analysis may be less susceptible to false-positive results, which result from carryover from previous pregnancies, than is the detection of fetal cells in maternal blood; also, rapid turnover may be useful for the monitoring of feto-maternal events with rapid dynamics.
1.2K
Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
Y.M. Dennis Lo,K.C. Allen Chan,Hao Sun,Eric Z. Chen,Peiyong Jiang,Fiona M.F. Lun,Yama W. Zheng,Tak Yeung Leung,Tze K. Lau,Charles R. Cantor,Rossa W.K. Chiu +10 more
TL;DR: This study shows that sequencing of maternal plasma DNA provides a way for noninvasive prenatal genome- wide scanning for genetic disorders and suggests the feasibility of using genome-wide scanning to diagnose fetal genetic disorders prenatally in a noninvasively way.
1.1K
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma.
Rossa W.K. Chiu,K.C. Allen Chan,Yuan Gao,Virginia Y. M. Lau,Wenli Zheng,Tak Yeung Leung,Chris H. F. Foo,Bin Xie,Nancy B.Y. Tsui,Fiona M.F. Lun,Benny Zee,Tze K. Lau,Charles R. Cantor,Y.M. Dennis Lo +13 more
TL;DR: Massively parallel plasma DNA sequencing represents a new approach that is potentially applicable to all pregnancies for the noninvasive prenatal diagnosis of fetal chromosomal aneuploidies.
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