Y Chen
Fox Chase Cancer Center
14 Papers
91 Citations
Y Chen is an academic researcher from Fox Chase Cancer Center. The author has contributed to research in topics: Cancer & Cancer stem cell. The author has an hindex of 5, co-authored 13 publications. Previous affiliations of Y Chen include Stanford University.
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Papers
Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity
Deryk T. Loo,Ralph Alderson,Francine Chen,Ling Huang,Wenjun Zhang,Sergey Gorlatov,Steve Burke,Valentina Ciccarone,Hua Li,Yinhua Yang,Tom Son,Y Chen,Ann Easton,Jonathan C. Li,Jill Rillema,Monica Licea,Claudia B. Fieger,Tony W. Liang,Jennie P. Mather,Scott Koenig,Stanford J. Stewart,Syd Johnson,Ezio Bonvini,Paul A. Moore +23 more
TL;DR: Evaluation of MGA271 clinical utility in B7-H3–expressing cancer is supported, while validating a combination of a nontarget biased approach of intact cell immunizations and immunohistochemistry to identify novel cancer antigens with Fc-based mAb engineering to enable potent antitumor activity.
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Calculation of x-ray transmission through a multileaf collimator.
Y Chen,Arthur L. Boyer,C.-M. Ma +2 more
TL;DR: A ray tracing based method has been developed to calculate the x-ray transmission through a multileaf collimator (MLC) for beam delivery verification and dose calculation in intensity modulated radiotherapy (IMRT) in better agreement with measurements using either film or a beam imaging system (BIS).
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A dose-volume histogram based optimization algorithm for ultrasound guided prostate implants.
Y Chen,Arthur L. Boyer,Lei Xing +2 more
TL;DR: An objective function sensitive to the DVHs of the target and critical structures is constructed, which is minimized using an iterative algorithm, starting from a randomly selected initial seed configuration.
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•Journal Article
The anti-B7-H3-4Ig antibody TES7 recognizes cancer stem cell lines, modulates angiogenic factor secretion, and exhibits potent anti-tumor activity in vivo
Claudia B. Fieger,Francine Chen,Suzanne Coberly,Mark Armanini,Y Chen,Jeff Hooley,Monica Licea,Jonathan Yu-Meng Li,Panjing Li,Tony W. Liang,Beverly Potts,Peter Young,Jennie P. Mather +12 more
TL;DR: This is the first report of regulation of angiogenic factors by tumor stem cells with an antibody that is aware of, and suggests that regulation of VEGF may contribute to the anti-tumor activity of TES7 observed in vivo.
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Monitor unit calculation for intensity modulated photon field
Lei Xing,Y Chen,Gary Luxton,Jinsheng Li,Arthur L. Boyer +4 more
- 23 Jul 2000
TL;DR: A closed formula for MU calculation in IMRT is derived and is illustrated by a simplified example and several CORVUS (NOMOS corporation) treatment plans, indicating that it is robust and suitable for IMRT MU verification.
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