Xusheng Yang

TL;DR: This study reveals that POSTN expression is increased in human and animal models of PH and fosters PH development via a positive feedback loop between HIF-1α and POSTN during hypoxia and proposes that manipulating POSTIN expression may be an efficacious therapeutic target in the treatment of PH.

TL;DR: It is shown that bile acids were downregulated during DR progression in the diabetic rat retinas and RMECs cultured in high glucose medium, suggesting that insufficient BA signaling plays an important pathogenic role in the development of DR.

TL;DR: Targeting of the SHF/STAT3 interaction is identified as a promising strategy for developing an optimal STAT3 inhibitor and early evidence of the potential clinical efficacy of STAT3 inhibitors such as C16 in GBM is provided.

TL;DR: It is demonstrated that SB203580 protected against inflammatory responses and lung injury by inhibiting lung edema and downregulating proinflammatory mediators in LPS‑induced lung injury.