Xun Wang
Sichuan University
7 Papers
65 Citations
Xun Wang is an academic researcher from Sichuan University. The author has contributed to research in topics: Bleomycin & Simvastatin. The author has an hindex of 5, co-authored 6 publications.
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Papers
VEGFR-2 antagonist SU5416 attenuates bleomycin-induced pulmonary fibrosis in mice.
Xuemei Ou,Wan-Cheng Li,Dai-Shun Liu,Yan-Ping Li,Fuqiang Wen,Yulin Feng,Shang-Fu Zhang,Xiang-Yang Huang,Tao Wang,Ke Wang,Xun Wang,Lei Chen +11 more
TL;DR: Results suggest that the VEGFR-2 inhibitor, SU5416, attenuates histopathologic fibroplasias and collagen deposition by regulating angiogenesis and inflammation in the lung.
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Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats
Lei Chen,Tao Wang,Xun Wang,Bei-Bei Sun,Ji-Qiong Li,Dai-Shun Liu,Shang-Fu Zhang,Lin Liu,Dan Xu,Ya-Juan Chen,Fuqiang Wen +10 more
TL;DR: In this article, the role of advanced glycation end products (AGEs) in pulmonary fibrosis was investigated using a bleomycin (BLM)-stimulated rat model treated with aminoguanidine (AG), a crosslink inhibitor of AGE formation.
Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway.
Ya-Juan Chen,Peng Chen,Haixia Wang,Tao Wang,Lei Chen,Xun Wang,Bei-Bei Sun,Dai-Shun Liu,Dan Xu,Jing An,Fuqiang Wen +10 more
TL;DR: The results suggest that simvastatin may attenuate acrolein-induced mucin protein synthesis in the airway and airway inflammation, possibly by blocking ERK activation mediated by Ras protein isoprenylation.
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Simvastatin attenuates experimental small airway remodelling in rats.
Xue Mei Ou,Fu Qiang Wen,Bruce D. Uhal,Yu Lin Feng,Xiang Yang Huang,Tao Wang,Ke Wang,Dai Shun Liu,Xun Wang,Lei Chen +9 more
TL;DR: The aim of this study was to assess the beneficial effects of simvastatin on cigarette smoke‐induced small airway remodeling in rats and to establish a protocol to evaluate the use of this drug in clinical practice.
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Toll-like receptor 4 relates to lipopolysaccharide-induced mucus hypersecretion in rat airway.
Lei Chen,Tao Wang,Jian-Yong Zhang,Shang-Fu Zhang,Dai-Shun Liu,Dan Xu,Xun Wang,Ya-Juan Chen,Fuqiang Wen +8 more
TL;DR: Results suggest TLR4 relates to LPS-induced AMH and support a role ofTLR4 in DEX inhibition of L PS-inducedAMH and show correlation analysis showed TLR 4 correlated well with the expression of MUC5AC.
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