9 Papers
33 Citations
Xun Chi is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: GPIHBP1 & Lipoprotein lipase. The author has an hindex of 8, co-authored 9 publications. Previous affiliations of Xun Chi include Roy J. and Lucille A. Carver College of Medicine & Zhejiang University.
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Papers
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase.
Xun Chi,Emily C. Britt,Hannah W. Shows,Alexander J. Hjelmaas,Shwetha K. Shetty,Emily M. Cushing,Wendy Li,Alex Dou,Ren Zhang,Brandon S.J. Davies +9 more
TL;DR: Data indicate that ANGPTL8 binds to Angiopoietin-like (ANGPTL3) and that this complex is necessary for ANGPTl3 to efficiently bind and inhibit LPL.
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Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome
Wei Yuan Hsieh,Quan D. Zhou,Autumn G. York,Kevin J. Williams,Philip O. Scumpia,Eliza B. Kronenberger,Xen Ping Hoi,Baolong Su,Xun Chi,Viet L. Bui,Elvira Khialeeva,Amber Kaplan,Young Min Son,Ajit S. Divakaruni,Jie Sun,Stephen T. Smale,Richard A. Flavell,Steven J. Bensinger +17 more
TL;DR: In this paper, the authors used complementary "shotgun" and isotope tracer mass spectrometry approaches to define the changes in lipid biosynthesis, import, and composition of macrophages induced by various Toll-like receptors (TLRs) and inflammatory cytokines.
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Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting
Emily M. Cushing,Xun Chi,Kelli L Sylvers,Shwetha K. Shetty,Matthew J. Potthoff,Brandon S.J. Davies +5 more
TL;DR: Angptl4 is induced early in fasting to divert uptake of fatty acids and triglycerides away from adipose tissues and this induction was suppressed in mice with access to food during the light cycle.
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Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins
Quan D. Zhou,Quan D. Zhou,Xun Chi,Min Sub Lee,Wei Yuan Hsieh,Jonathan J. Mkrtchyan,An-Chieh Feng,Cuiwen He,Autumn G. York,Autumn G. York,Autumn G. York,Viet L. Bui,Eliza B. Kronenberger,Alessandra Ferrari,Xu Xiao,Allison E. Daly,Elizabeth J. Tarling,Robert Damoiseaux,Philip O. Scumpia,Stephen T. Smale,Kevin J. Williams,Peter Tontonoz,Steven J. Bensinger +22 more
TL;DR: It is reported that interferon (IFN) signals convey resistance to CDC-induced pores on macrophages and neutrophils, and interferons promote host cell resistance to bacterial cytolysins by decreasing cholesterol synthesis and promoting the esterification of cholesterol, which alters the availability of this pool of ‘free’ cholesterol needed for pore formation.
Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane.
Alessandra Ferrari,Cuiwen He,John Paul Kennelly,Jaspreet S. Sandhu,Xu Xiao,Xun Chi,Haibo Jiang,Stephen G. Young,Peter Tontonoz +8 more
TL;DR: Investigating the PM pool of accessible cholesterol in cholesterol-loaded fibroblasts with a knockdown of Aster-A and in mouse macrophages from Aster-B and Aster-a/B-deficient mice revealed expansion of the accessible cholesterol pool in cells lacking Aster expression, and revealed that the Aster-mediated nonvesicular cholesterol transport pathway controls levels ofaccessible cholesterol in the PM, as well as the activity of the SREBP pathway.
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