Xueyi Chen
University of Alberta
10 Papers
23 Citations
Xueyi Chen is an academic researcher from University of Alberta. The author has contributed to research in topics: Medicine & Protein kinase B. The author has an hindex of 7, co-authored 10 publications.
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Papers
Apelin Is a Negative Regulator of Angiotensin II-Mediated Adverse Myocardial Remodeling and Dysfunction.
Zhen-Zhou Zhang,Wang Wang,Hai-Yan Jin,Xueyi Chen,Yu-Wen Cheng,Ying-Le Xu,Bei Song,Josef M. Penninger,Gavin Y. Oudit,Jiu-Chang Zhong +9 more
TL;DR: In this article, the role of pyr1-apelin-13 peptide pathway in angiotensin (Ang) II-mediated heart disease was investigated in young apelin-deficient (APLN/y) and apolipoprotein E knockout mice.
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PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease
Vaibhav B. Patel,Vaibhav B. Patel,Pavel Zhabyeyev,Xueyi Chen,Faqi Wang,Manish Paul,Dong Fan,Brent A. McLean,Ratnadeep Basu,Pu Zhang,Saumya Shah,John F. Dawson,W. Glen Pyle,Mousumi Hazra,Zamaneh Kassiri,Saugata Hazra,Bart Vanhaesebroeck,Christopher A. McCulloch,Gavin Y. Oudit +18 more
TL;DR: Gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytoskeletal remodeling and heart failure.
Recombinant Human ACE2 and the Angiotensin 1-7 Axis as Potential New Therapies for Heart Failure.
TL;DR: Improvement in endothelial dysfunction, suppression of tissue inflammation and myocardial fibrosis, correction of metabolic dysfunction, and reversal of pathological hypertrophy are the key beneficial effects seen when ACE2 or Ang 1-7 action are enhanced.
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Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts.
TL;DR: Pharmacological inhibition of PI3Kα is arrhythmogenic due to activation of INa-L leading to increased sarcoplasmic reticulum Ca2+ load and prolonged QT interval, therefore, monitoring of cardiac electrical activity in patients receivingPI3K inhibitors may provide further insights into the arrhythogenic potential ofPI3Ka inhibition.
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PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias.
TL;DR: Recent advances in preclinical models demonstrate an important role of PI3Kα in the control of cytoskeletal integrity, Na+ channel activity, cardioprotection, and prevention of arrhythmias.
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