Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality, all over the world. COPD, which was the sixth leading cause of death worldwide in 1990, will become the third one in 2020. COPD is a complex disease, influenced by genetic, behavioral, and environmental factors. The most important factor for developing COPD is tobacco smoke. Also environmental conditions represents risk for developing COPD. Furthermore, diet and a low socioeconomic status are correlated to the disease. Genetic factors, familial history, and childhood lower respiratory tract infections play an important role in the etiology of COPD. Burden of COPD is very high for community. Furthermore, the disease often is under-diagnosed and treated only at advanced stages, whilst it is a substantial health problem even among young adults. This needs to be taken into account by health personnel and decision-makers.

Epidemiology of chronic obstructive pulmonary disease

/pdf/epidemiology-of-chronic-obstructive-pulmonary-disease-eul8kk0nia.pdf

Epidemiology of Chronic Obstructive Pulmonary Disease.

OBJECTIVE: To study whether familial aggregation exists in pulmonary function impairment and COPD. METHODS: Pulmonary function, smoking habits, history of occupational dust exposure and clinical manifestation among 117 children of 59 smokers with COPD and 55 children of 28 control smokers without COPD. A multivariate linear regression analysis was carried out to study FEV1 among the children. Logistic regression analysis was conducted to study the factors influencing the FEV1 < 70% pred. RESULTS: Height and male gender were positively correlated to children's FEV1 (ml); whereas age, clinical symptoms, history of occupational dust exposure and being children of diseased probands were negatively correlated to children's FEV1 (ml). With other relevant factors adjusted, the FEV1 (ml) was lower among those being children of COPD patients; the more severe the COPD conditions of the parents, the lower the FEV1 of the children. Cigarette consumption having clinical symptoms, and being children of COPD probands showed increased risk of FEV1 below 70% predicted (OR = 1.987). Height, age, and history of occupational dust exposure were not correlated to FEV1 < 70% pred among children. CONCLUSION: Being children of COPD parents is the independent risk factor for lower FEV1 (ml) and FEV1 below 70% pred, which demonstrates the presence of familial aggregation of COPD and pulmonary function impairment.

[Pulmonary function in first generation children of chronic obstructive pulmonary disease (COPD) patients: assessment of related predicting factors].

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[Pulmonary function in first generation children of chronic obstructive pulmonary disease (COPD) patients: assessment of related predicting factors].